DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-B and pigb

DIOPT Version :9

Sequence 1:	NP_647832.1	Gene:	PIG-B / 38446	FlyBaseID:	FBgn0035464	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_956770.1	Gene:	pigb / 393448	ZFINID:	ZDB-GENE-040426-1216	Length:	536	Species:	Danio rerio

Alignment Length:	541	Identity:	217/541 - (40%)
Similarity:	314/541 - (58%)	Gaps:	63/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAGLY 68
            |.:.:.|:.|||.:..:|||.:||||:|||||::|::.|||||.||||.:|||.|.||||.|.:|
Zfish    43 INITVFIVLVRLLNCVLVQTSFVPDEFWQSLEISHRMVFGYGYETWEWKEGIRGYSYPLLFALMY 107

  Fly    69 KILALLQLDSAHLLVVLPRIVQALLSAYSDYRFF----VW--TGKRKWALFLILVPWFWFYTGSR 127
            |:|.|:..|:.:|||.:||:.||||:||:|.:.:    .|  ....||..|..|..||.::..||
Zfish   108 KLLQLISYDTVYLLVFVPRVFQALLAAYADVKLYKLILQWETPDVAKWTCFCQLCSWFAWFCCSR 172

  Fly   128 TLANTLEASLTTIALSYFPWYGEST----AYLWPAAICCFLRPTAAVIWLPLSLYHLRRSRQNVL 188
            ||.||.|.:|||:||.::|..|..|    .||...::...:||||.::|.||..||. .:.|:.|
Zfish   173 TLTNTTETALTTLALCFYPLPGSKTHSSWKYLTLVSLAVVIRPTALIVWFPLIFYHF-CTDQDKL 236

  Fly   189 ELILKRFVLIGLLVAGLGIAIDTYWHGQLIVTPYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTV 253
            :||..|:..||:|..|:...||::::|:.|...:.|||:|:.:|:|.||||||||||::.|||.|
Zfish   237 KLITHRYFPIGVLALGVSTLIDSFFYGKWIFVQWNFLKFNVLHNVGEFYGSHPWHWYWTQGLPVV 301

  Fly   254 LGINTLPFIF-GVMETVKKSEKYPVSKQLLITIFLTLVVLSAVEHKEFRFVSPLLPLCLYVITDA 317
            :|.: ||.:. |.:.:.:|      ...||:||..|..|.|.:.||||||:.|:||.|:  |...
Zfish   302 IGPH-LPLVLHGCLLSTRK------HTILLLTIIWTTAVYSLLAHKEFRFIYPVLPFCM--IFCG 357

  Fly   318 LSRWSIRASSTMLWTTAL--VILVGNVMPAWYLSTVHQKGPIELMPKLREIAREYRDEREHQANI 380
            ||...::|     |..|.  .:|:.|:.||.|...|||:|.:::|..|:.:.  ...:..:...:
Zfish   358 LSLAKLQA-----WRKAAAGALLLFNLCPALYTGLVHQRGALDVMHVLQPLC--VSSQSPNPPEL 415

  Fly   381 LFLMPCHSTPYYSHIHQNVTMRFLTCEPNLEKKEQYKDEADRFFEDPVHWINSHIPMHPLTALPT 445
            ||||||||||.|||:|..:.:|||.|.|:|..::.|.||||.||.||:||:|:..|:.  :.||:
Zfish   416 LFLMPCHSTPLYSHLHCPLKLRFLECPPDLTGRQDYMDEADVFFSDPLHWLNTSFPLR--STLPS 478

  Fly   446 HVVLFDPLAENISVFLRNYRLLHRIEHAEVTRLEGSQALVDQWSEALGAQSPNLASLLQNRQSRT 510
            |:||||.|.:.||.||.                |.|.|   :.:|......|         :.|.
Zfish   479 HLVLFDSLQKEISSFLE----------------ENSFA---KQAEIFHTHFP---------EGRV 515

  Fly   511 GRSILVYQRLKKGEENAFNRG 531
            |::||:|.|   ..|...|.|
Zfish   516 GKNILIYSR---RSEMKINEG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-B	NP_647832.1	Glyco_transf_22	5..396	CDD:281842	170/403 (42%)
pigb	NP_956770.1	PMT_2	45..514	CDD:304453	207/515 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592203
Domainoid	1	1.000	322	1.000	Domainoid score	I1198
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3570
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1974
OMA	1	1.010	-	-		QHG54776
OrthoDB	1	1.010	-	-		D281304at33208
OrthoFinder	1	1.000	-	-		FOG0005162
OrthoInspector	1	1.000	-	-		oto39242
orthoMCL	1	0.900	-	-		OOG6_103087
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R510
SonicParanoid	1	1.000	-	-		X3680
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940