DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-B and gpi10

DIOPT Version :9

Sequence 1:	NP_647832.1	Gene:	PIG-B / 38446	FlyBaseID:	FBgn0035464	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_587993.1	Gene:	gpi10 / 2539152	PomBaseID:	SPCC16A11.06c	Length:	506	Species:	Schizosaccharomyces pombe

Alignment Length:	567	Identity:	165/567 - (29%)
Similarity:	265/567 - (46%)	Gaps:	113/567 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IYVFLLILAVRLASVFVVQTYYVPDEYWQSLEVAHKLTFGYGYLTWEWVQGIRSYVYPLLIAGLY 68
            |:.:|.||..|..:...|:|::.|||::|||||||...|.||:|||||...|||.::||:.|.||
pombe     3 IWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALY 67

  Fly    69 KILALLQLDSAHLLVV-LPRIVQALLSA---YSDYRF-FVWTGKR--KWALFLILVPWFWFYTGS 126
            ::|.:|:|||::.:.. .|:::|...:|   |..|:| .|..|.:  .|.|...||.....|.|.
pombe    68 RVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGV 132

  Fly   127 RTLANTLEASLTTIALSYFPW---------------YGESTAYLWPAAICCFLRPTAAVIWL-PL 175
            ||.:|:||.:||:|...||.:               |.....::..||..||:|||..::|: ||
pombe   133 RTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPL 197

  Fly   176 SLYHLRRSRQNVLELILK--------RFV-------LIGLLVAG-----LGIAIDTYWHGQLIVT 220
            ..::  ::.|..::.:|.        ||:       |.|:.|..     :.|..|...:|:.:..
pombe   198 LFWN--KNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFP 260

  Fly   221 PYEFLKYNIFNNIGSFYGSHPWHWYFSVGLPTVLGINTLPFIFGVMETVKKSEKYPVSKQLLITI 285
            ...|.::|:.:.:.|.||.:.||:|.|..||.:.| ..|||:...|:.           |...||
pombe   261 IISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICG-GFLPFVLLTMDL-----------QTAGTI 313

  Fly   286 FLTLVVLSAVEHKEFRFVSPLLPLCLYVITDALSRWSIRASSTMLWTTA----LVILVGNVMPAW 346
            .......|.:.|||.|||.|:.|:.|.:.....|.:|       .|..|    .:|.:|:.:...
pombe   314 LCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFS-------SWKRAARFFFLIGLGHALVIT 371

  Fly   347 YLSTVHQKGPIELMPKLREIAREYRDEREHQANILFLMPCHSTPYYSHIHQNVT---MRFLTCEP 408
            :|...||.|.:|:||.:..:|       |.....|.|.|||:||:.||||....   .:||||||
pombe   372 FLCRFHQFGVMEVMPLIHSLA-------EKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTCEP 429

  Fly   409 NLEKKEQYKDEADRFFEDPVHWINSHIPMHPLTALPTHVVLFDPLAENISVFLRNYRLLHRIEHA 473
                .|:..||.|||:|:...:::.      :...|.:::.|:....::..:|.:    ..:::.
pombe   430 ----FEKPFDETDRFYENMPTFLDK------IKEWPDYLIFFEERFYSLYSYLDS----RGLKYE 480

  Fly   474 EVTRLEGSQALVDQWSEALGAQSPNLASLLQNRQSRTGRSILVYQRL 520
            ||.|...                    ||:...:.|.| ::|||::|
pombe   481 EVQRYYN--------------------SLIPESRERAG-ALLVYKKL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-B	NP_647832.1	Glyco_transf_22	5..396	CDD:281842	135/437 (31%)
gpi10	NP_587993.1	Glyco_transf_22	4..414	CDD:281842	135/437 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	198	1.000	Domainoid score	I671
eggNOG	1	0.900	-	-		E1_KOG1771
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	215	1.000	Inparanoid score	I930
OMA	1	1.010	-	-		QHG54776
OrthoFinder	1	1.000	-	-		FOG0005162
OrthoInspector	1	1.000	-	-		oto101118
orthoMCL	1	0.900	-	-		OOG6_103087
Panther	1	1.100	-	-	LDO	PTHR22760
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R510
SonicParanoid	1	1.000	-	-		X3680
TreeFam	1	0.960	-	-
	13	12.860