Protein Alignment IntS10 and INTS10

DIOPT Version :10

• Sequence 1: NP_647830.1
• Gene: IntS10 / 38444
• FlyBaseID: FBgn0035462
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001340434.1
• Gene: INTS10 / 55174
• HGNCID: 25548
• Length: 737
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 178/760 - (23%)
• Similarity: 313/760 - (41%)
• Gaps: 170/760 - (22%)

  Fly     1 MPSQEENELYMVKEAQRLRKSDPCAAMAWIITAKTLYPNAFNLQYEAYLLERDAQNYEEAAKCFS 65
            |.:|.:.| ::|:.|:.|...|..||.||:|||::|||..||:|||.|.:||:|:....|.:...
Human     1 MSAQGDCE-FLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLY 64

  Fly    66 AIATNFQNQHTELWQEINSLTNALRNENETTPEHEFYVKMYKHLTPEVQHNIFMHTINHSADNLE 130
            .:..||.:|.. :|:||:.:|:||||::: ..:.:|...:::.|...||..:.:.......:.||
Human    65 DMFVNFPDQPV-VWREISIITSALRNDSQ-DKQTQFLRSLFETLPGRVQCEMLLKVTEQCFNTLE 127

  Fly   131 RIYIYILMFNKFPKSAITQAPRLLEMLAEGMKTEP-----DLYQRILVEEVLPM-IQNKPPELSP 189
            |..:.:|:..:||::.:.....|.|.|.|....|.     :.::::.|.:|||: |.|....|..
Human   128 RSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPA 192

  Fly   190 NLACRLYTSSLEFYLRQI-------------MDESD-----------------------TADAWK 218
            ||..:....:.|||:..:             .|.||                       ..|.|:
Human   193 NLLYKYLNKAAEFYINYVTRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWE 257

  Fly   219 NIFKVLMICGQMMGWE-------------------------PFLPFSKHVNQNVYWEKLV----- 253
            .:||:|.:.|....|:                         .....:|:.||.||...||
Human   258 RLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTMLVFFKNA 322

  Fly   254 ---------DILSGSPAGSSQVLFYATTLF--IYSLHGYIRNCKLRIEDADV---THV-----LV 299
                     .:..| |...|||   ...|.  :.:::|          |.::   .|:     |.
Human   323 FQYVNSIQPSLFQG-PNAPSQV---PLVLLEDVSNVYG----------DVEIDRNKHIHKKRKLA 373

  Fly   300 EGFMEWSPEGDGSEVPSMEPPKFSLTT----AISPELSKAFLHAAQCWQLLNTDQF-QRDFSQLM 359
            ||..:.....|..:..:....:..:..    |.|.|:.::|..|.:.|:||.:.:| .::|:::.
Human   374 EGREKTMQSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESWELLYSLEFLDKEFTRIC 438

  Fly   360 LALPLAP--WISRFLFDLAIYFGHRDEANKLMADMTTQSSLVQSLQILSLNLMQGSMTLQGFQCI 422
            ||.....  |:..||.|:.||.|   :..|.:|.:...::|..|   :|...:.|..||:..:.:
Human   439 LAWKTDTWLWLRIFLTDMIIYQG---QYKKAIASLHHLAALQGS---ISQPQITGQGTLEHQRAL 497

  Fly   423 LKI------LSELPTTQGQLLENMSL-----------------------KGHRHMVFLPLTRSAL 458
            :::      |.|...|..::|:.|..                       || ..:..||.|..|:
Human   498 IQLATCHFALGEYRMTCEKVLDLMCYMVLPIQDGGKSQEEPSKVKPKFRKG-SDLKLLPCTSKAI 561

  Fly   459 VQYCVGAIISRLSRKVFEPNVPDRLLGDILVLQQLNLLNDVLLTQQIFNLIKQRKSFNLRTLSTY 523
            :.||:..:::....:.|..|..|..||.::||.|........|..:..|.|.|:.:|.......|
Human   562 MPYCLHLMLACFKLRAFTDNRDDMALGHVIVLLQQEWPRGENLFLKAVNKICQQGNFQYENFFNY 626

  Fly   524 IINIDLLEELSHIWNSQQEDNFELTSSPNS------SGTPTA-----------TTVAGGSQSRRI 571
            :.|||:|||.::: .:|:.....|...||.      |..|..           .::....:...:
Human   627 VTNIDMLEEFAYL-RTQEGGKIHLELLPNQGMLIKPSSPPMGLLQQEFLPVLQPSIQTADRHHTV 690

  Fly   572 GTRGADKGARDEFRAITRQQIARCNENVITLLANFINQEHLMLAQ 616
             |||..||.:::||....:|::||.||::.:|..|...|.::|.|
Human   691 -TRGITKGVKEDFRLAMERQVSRCGENLMVVLHRFCINEKILLLQ 734