Protein Alignment ppk27 and ASIC3

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 97/531 - (18%)
• Similarity: 159/531 - (29%)
• Gaps: 197/531 - (37%)

  Fly    20 SLNGFGLLYFIRKRRIQRIFWFLFISFGILFASYAVFSMVLEF--LSYSTIADLSELKVLEDEIH 82
            |::|.|.::......::|..|...:...:....|.|...|..:  ..:.|..|       |.|.|
Human    25 SMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-------ERESH 82

  Fly    83 ---FPELKICSGYKFSYRNMLASAHDLVSSQNKSLDYWLNKLSLLSGYFDALSVKAENVDDLNSL 144
               ||.:.:|:....  |....:.:||         :|..  |.|.|
Human    83 RLIFPAVTLCNINPL--RRSRLTPNDL---------HWAG--SALLG------------------ 116

  Fly   145 LDIKNISSFLLAL--TPA----------------------CESLILKCKLNNIPA---NCLKLFT 182
            ||....::||.||  .||                      .:.::|.|:....|.   |...:||
Human   117 LDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFT 181

  Fly   183 LKAYNDGNCCVLRNSNLTGE-------------LTLFMDSSQIDEYPL---NGNLP---GFSLHV 228
                ..|.|... ||...|.             |.:.:|..|.:..|:   |...|   |..:.:
Human   182 ----RMGKCYTF-NSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQI 241

  Fly   229 PSW-------QGRVSINPGEMAAVEIEVMELQ---------GNSQLN-EYAVE------------ 264
            .|.       |..:.::||....|..:..:|.         .::.|| .|..|
Human   242 HSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSP 306

  Fly   265 ---------KRACYFSQEGESREKCLHECRIKATLINCQCVPYPFEF---RTQKFGYCTLENIRC 317
                     :.||              |.|..|....|:.|..|.:.   ..|::..|....|..
Human   307 SPPYTLMGCRLAC--------------ETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDA 357

  Fly   318 LQLVERNWSPAQCPQCLPLCNQLFYRLNKQILGHLHPWRSELNFKFKTPHRQR--YKTNIL---- 376
            :...:....|..|...         |..|::.....|.|:...|..:..:|..  ...|:|
Human   358 MLRKDSCACPNPCAST---------RYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDI 413

  Fly   377 ---------------YHWYQMLSNVGGVLGICIGCSFISGFELIYFL--VFR------LW----- 413
                           |...::|.::||.:|:.||.|.::..|::.:|  |||      .|
Human   414 FFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHS 478

  Fly   414 -----TNYLRQ 419
                 ||.|::
Human   479 QRHSSTNLLQE 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	89/499 (18%)
ASIC3	NP_064717.1	ENaC	20..534	CDD:273304	97/531 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		4/21 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	447..449		1/1 (100%)