Protein Alignment ppk27 and asic1a

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_999955.1
• Gene: asic1a / 791696
• ZFINID: ZDB-GENE-040513-2
• Length: 501
• Species: Danio rerio
• Alignment Length: 485
• Identity: 93/485 - (19%)
• Similarity: 164/485 - (33%)
• Gaps: 137/485 - (28%)

  Fly    13 VEYFRKTS-LNGFGLLYFIRKRRIQRIFWFLFISFGILFASYAVFSMVLEFLSYSTIADLSELKV 76
            ::.|..|| |:|...::...|...:...|.:|....:.|..|.....:..:|.|..:..|.|  :
Zfish    23 LQVFAHTSTLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLDE--I 85

  Fly    77 LEDEIHFPELKIC--SGYKFS--YRNMLASAHDLVSSQNKSLDYWLNKLSLLSGYF---DALSVK 134
            ....:.||.:.||  :..:||  .||.|..|.:|              |:||:...   :|..|:
Zfish    86 TTPVMVFPAVTICNLNSIRFSRITRNDLYHAGEL--------------LALLNSRHEVREAHLVE 136

  Fly   135 AENVDDLNSLLDIK-------NISSFLLALTPACESLILKCKLNNIPANCLKLFTLKAYNDGNCC 192
            ...::.|.|..|.:       |:..|........:.::|.|:....|.. .:.|::.....|.|.
Zfish   137 ESVMEVLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCR-PEDFSVVFTRYGKCY 200

  Fly   193 VLRNSNLTGE------------LTLFMDSSQIDEY-PLNGN------------------------ 220
            .. ||..||.            |.:.:|..| ||| |:.|.
Zfish   201 TF-NSGETGPPRVSVKGGMGNGLEIMLDIQQ-DEYLPVWGESDESSFEAGIKVQIHSQDEPPFID 263

  Fly   221 ------LPGFSLHVPSWQGRVSINPGEMAAVEIEVMELQGNSQLNEYAVEKRACYFSQEGESREK 279
                  .|||...|...:.|:...|....:.:               :....:.||  ...|...
Zfish   264 QLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCK---------------STPPSSDYF--RAYSISA 311

  Fly   280 CLHECRIKATLINCQC--------VPY--PFEFRTQKFGYCTLENIRCLQLVERNWSPAQCPQCL 334
            |..:|..:..:.||.|        .||  |..::.     |....:..|...:.::...:.|
Zfish   312 CRTDCETRYLVENCNCRMVHMPGDAPYCTPVLYKE-----CAHPALDFLVETDSDYCSCETP--- 368

  Fly   335 PLCNQLFYRLNKQILGHLHPWRSELNFKFKTPHR-QRYKT-NIL-------------------YH 378
              ||  ..|.:|::.....|.::.:.:..|...: ::|.| |::                   |.
Zfish   369 --CN--ITRYSKELSFVKIPSKASVKYLAKKYSKSEKYITENVMVLDVFFEALNYETIEQRKAYE 429

  Fly   379 WYQMLSNVGGVLGICIGCSFISGFELIYFL 408
            ...:|.::||.:|:.||.|.::..||..:|
Zfish   430 VAGLLGDIGGQMGLFIGASILTILELFDYL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	92/480 (19%)
asic1a	NP_999955.1	ENaC	23..469	CDD:273304	93/485 (19%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:Q1XA76	446..448		1/1 (100%)