DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk27 and SCNN1G

DIOPT Version :10

Sequence 1:NP_647826.2 Gene:ppk27 / 38440 FlyBaseID:FBgn0035458 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_001030.2 Gene:SCNN1G / 6340 HGNCID:10602 Length:649 Species:Homo sapiens


Alignment Length:578 Identity:120/578 - (20%)
Similarity:194/578 - (33%) Gaps:210/578 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 TVVEYFR----KTSLNGFGLLYFIRKRRIQRIFWFLFISFGILFASYAVFSMVLEFLSYSTIADL 71
            |:.|..|    .|:.:|...: .:.:.|::|:.|   |.|.:...:..::...|...|:.|::  
Human    24 TIKELMRWYCLNTNTHGCRRI-VVSRGRLRRLLW---IGFTLTAVALILWQCALLVFSFYTVS-- 82

  Fly    72 SELKVLEDEIHFPELKIC--SGYKFS-YRNMLASAHDLVSSQNKSL------------DYW---- 117
            ..:||...::.||.:.||  :.||:| .|::||..........|||            :.|    
Human    83 VSIKVHFRKLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVS 147

  Fly   118 -------LNKLSLLSGYFD--------------------ALSVKAENVDDLNSLLDIKNISSF-- 153
                   .:::.||  .||                    ::..||.||..:.|    |.:..|  
Human   148 EGKQPRFSHRIPLL--IFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIES----KQVVGFQL 206

  Fly   154 ------------------------------LLALTP---------ACESLILKCKLNNIPANCLK 179
                                          ::|..|         :.|.|::.|..:.:..:. :
Human   207 CSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDA-R 270

  Fly   180 LFTLKAY-NDGNCCVLRNSNLTGELTLFMDSSQ--------IDEYPLNGNLPGFSLHVPSWQGRV 235
            .|||..: ..|||....|......|:..|..|:        |:|...|..|      |.|...:|
Human   271 NFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFL------VSSTGAKV 329

  Fly   236 SINPG------EMAAVEIEV-------MELQGNSQLNE-YA--------VEKRACYFSQEGESRE 278
            .|:..      |....|||.       |.|..:.:|:| |:        |..|..|  ....|.:
Human   330 IIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCTEDGSDVPIRNIY--NAAYSLQ 392

  Fly   279 KCLHECRIKATLINCQCVPYPFEFRTQKF----GYCTL-------------------ENIRCLQL 320
            .|||.|.....:..|.|..|     :|..    .||..                   |.:.|..:
Human   393 ICLHSCFQTKMVEKCGCAQY-----SQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSV 452

  Fly   321 VE-----RNW----SPAQCPQ------CLPLC-----NQLFYRLNKQILGHLHPWRSELNFK--F 363
            .:     :.|    |.||.|.      .||:.     .|:..:|||..|..|..:..:||.:  .
Human   453 CKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQRSIM 517

  Fly   364 KTPHRQRYKTNILYHWYQMLSNVGGVLGICIGCSFISGFELI--YFLVF------RLW 413
            ::|      .|.:   ..:|||.||.||:.:.||.:...|:|  :|:.|      |.|
Human   518 ESP------ANSI---EMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQW 566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk27NP_647826.2 ASC 15..407 CDD:459966 114/560 (20%)
SCNN1GNP_001030.2 ENaC 24..630 CDD:273304 120/578 (21%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000269|PubMed:30251954, ECO:0000269|PubMed:32729833 135..221 12/91 (13%)
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:17502380 623..627
Blue background indicates that the domain is not in the aligned region.

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