Protein Alignment ppk27 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 107/560 - (19%)
• Similarity: 187/560 - (33%)
• Gaps: 176/560 - (31%)

  Fly     8 FNKTVVEYFRKTSLNGFGLLYFIRKRRI-----QRIFWFLFISFGILFAS-----YAVFSMVLEF 62
            :.:.:|.|...|:.:|       .||.|     ::..|||..   :|||:     :.:|  :..:
Human    41 YKELLVWYCDNTNTHG-------PKRIICEGPKKKAMWFLLT---LLFAALVCWQWGIF--IRTY 93

  Fly    63 LSYSTIADLS-ELKVLEDEIHFPELKICSGYKFSY---RNMLASAHDLV---------------- 107
            ||:.....|| ..|.::    ||.:.||:...|.|   :::|....:|:
Human    94 LSWEVSVSLSVGFKTMD----FPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHAN 154

  Fly   108 SSQNKSLDYWLNK---------------LSLLSGYFDALSVK--------------AENVDDLN- 142
            :::|.:...|.:.               |.|.....:.|:..              |..:..||
Human   155 ATRNLNFSIWNHTPLVLIDERNPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNR 219

  Fly   143 SLLDIKNISSFLLALT------------------------PACESLILKCKLNNIPANCLKLFTL 183
            :....:|.:|...|||                        |. |.:||.|.....|.|.....::
Human   220 TQCTFRNFTSATQALTEWYILQATNIFAQVPQQELVEMSYPG-EQMILACLFGAEPCNYRNFTSI 283

  Fly   184 KAYNDGNCCV---------LRNSNLTGE--LTLFMDSSQIDEYPLNGNLPGFSLHVPSWQGRVSI 237
            ...:.|||.:         |.::|...|  |.|.:|..|.|..|...:..|..|.:...:....|
Human   284 FYPHYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGVRLMLHEQRSYPFI 348

  Fly   238 N-------PGEMAAVEIEVMELQGNSQL--------NEYAVEKRACYFSQEGE--SREKCLHECR 285
            .       .|...::.:.|.:||...:.        :|..|:.   ::|....  |.:.||..|.
Human   349 RDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQN---FYSDYNTTYSIQACLRSCF 410

  Fly   286 IKATLINCQCVPYPFEF-RTQKFGYCTLENI----RC---LQLVERNWSPAQCPQCLPLCNQLFY 342
            ....:.||.|..|.:.. |.:|  ||...:.    .|   ||:     |.||...|:.:|.:...
Human   411 QDHMIRNCNCGHYLYPLPRGEK--YCNNRDFPDWAHCYSDLQM-----SVAQRETCIGMCKESCN 468

  Fly   343 RLNKQILGHLHPWRSELN----FKFKTPHRQR-----------YKTNILYHWYQ----------- 381
            ....::...:..|.||.:    |...:..|.:           .|.||.:..:.
Human   469 DTQYKMTISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANN 533

  Fly   382 ---MLSNVGGVLGICIGCSFISGFELIYFLVFRLWTNYLR 418
               :|||:||..|..:|.|.:...|....::..:|...::
Human   534 IVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIK 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	105/540 (19%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	107/560 (19%)