Protein Alignment ppk27 and ASIC5

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 101/489 - (20%)
• Similarity: 182/489 - (37%)
• Gaps: 163/489 - (33%)

  Fly    25 GLLYFIRKR-RIQRIFWFLFISFGILFASYAVFSMVLEFLSYSTIADLSELKVLEDEIHFPELKI 88
            |:...::.| :|:|:.|.:.:...:...::.::..:|.:.::.|...: |::.:| ::.||.:..
Human    49 GIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSI-EVQYVE-KMEFPAVTF 111

  Fly    89 CSGYKFS--------------------------YRNMLAS--AHDLVSS-QNKSL-DYWLNKLSL 123
            |:..:|.                          ..|...|  |.|..:| ||.|: ::..||
Human   112 CNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNK--- 173

  Fly   124 LSGYFDALSVKAENVDDLN--SLLDIKNISSFLLALTPACESLILKCKLNNIPANCLKLFTLKAY 186
              |::            ||  :|||              ||.....|.    |.:...:||
Human   174 --GFY------------LNNSTLLD--------------CEFFGKPCS----PKDFAHVFT---- 202

  Fly   187 NDGNCCVL---------RNSNLTGE-LTLFMDSSQ--IDEYPLNGNLPG---FSLH----VPSWQ 232
            ..|||...         |..:::|. |:|..:.:|  ..:.|..|.:..   |.:|    ||.:.
Human   203 EYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFD 267

  Fly   233 GRVSINP-GEMAAVEIEVM----------ELQGNSQLNEYAVEKRACYFSQEGESREKCLHECRI 286
            |...::| |..|.|.|..:          |...|.:|..::      .:|..|     ||.||:.
Human   268 GLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFS------SYSTSG-----CLKECKA 321

  Fly   287 KATLINCQCVP-----YPFEFRTQKFGYC---TLENIRCLQLVERNWSPAQCPQCLPLCNQLFY- 342
            :.....|.|||     |..|...||:..|   .|::|....|.......:.||..   |.::.|
Human   322 QHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVS---CEEIEYP 383

  Fly   343 -------------------RLN------KQILGHLHPWRSELNFKFKTPHRQRYKTNILYHWYQM 382
                               :||      ::.|..:....|:||:|..   :|:...::    .::
Human   384 ATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKIT---QQQKAVSV----SEL 441

  Fly   383 LSNVGGVLGICIGCSFISGFELIYFLVFRLWTNY 416
            |:::||.||:..|.|.|:..|:|.:    |:||:
Human   442 LADLGGQLGLFCGASLITIIEIIEY----LFTNF 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	98/478 (21%)
ASIC5	NP_059115.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	98/478 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)