Protein Alignment ppk27 and asic4b

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_999951.1
• Gene: asic4b / 407667
• ZFINID: ZDB-GENE-040513-6
• Length: 558
• Species: Danio rerio
• Alignment Length: 492
• Identity: 96/492 - (19%)
• Similarity: 164/492 - (33%)
• Gaps: 146/492 - (29%)

  Fly    12 VVEYFRKTSLNGFGLLYFIRKR-RIQRIFW--FLFISFGILFASYAVFSMVLEFLSYSTIADLSE 73
            :..:...:||:|........:| ..::..|  .|.:|.| ||...|.:| ...:|....:|.|.|
Zfish    44 LASFASSSSLHGLARALGTSERLGFRQTLWGLALLVSLG-LFLYQATWS-AATYLERPHLAALRE 106

  Fly    74 LKVLEDEIHFPELKICSGYKFSYRNMLASAHDLVSSQNKSLDYWLNKLSLLSGYFDALSVKAENV 138
              ....|:.||.:.:|:..:|.:..:              .|..:..|:.|:| ....|.|....
Zfish   107 --ETRRELTFPAITLCNVNRFRFSAL--------------TDADIYHLANLTG-LPPKSRKGHRP 154

  Fly   139 DDLN----SLLDIKNISSFLLALTPACESLILKCKLNNIPANCLKLFTLKAYNDGNCCVLRNSNL 199
            .:|.    ::|||...:...|      |.::..|..:.  .||........|.....|...|.|.
Zfish   155 SELQYPPPNMLDIFQRTGHQL------EDMLKSCNFSG--QNCSSEDFSVVYTRYGKCYTFNGNK 211

  Fly   200 TGE-----------LTLFMDSSQIDEYPLNGNLPGFSLHVPSWQG----------RVSI------ 237
            |..           |.:.:|..| |||            :|.|:.          ||.|
Zfish   212 TSPKRVRQGGTGNGLEMMLDIQQ-DEY------------LPIWRETNETTLEAGIRVQIHSQNEP 263

  Fly   238 ----------NPGEMAAVEIEVMELQ------GNSQLNE---------YAVEKRACYFSQEGESR 277
                      :||....|..:...|.      ||.:.:.         |:|.  ||....|....
Zfish   264 PYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWGNCRASSEPVIPGYDTYSVS--ACRLHCESTQV 326

  Fly   278 EKCLHECRIKATLINCQCVPYPFEFRTQKFGYCTLENIRCLQLVERNWSPAQ------CPQCLPL 336
            ::   ||       ||:.|..|.:     ...|....|:|   |::..:..|      || |...
Zfish   327 QR---EC-------NCRMVHMPGD-----ADICAPSKIKC---VDKALASLQKSTGDSCP-CETP 372

  Fly   337 CNQLFY-----------RLNKQILGHLHPWRSE--------LNFKFKTPHRQRYKTNILYHWYQM 382
            ||...|           |.:.:.|...:....|        |:..|:..:.:..:....|....:
Zfish   373 CNLTRYGKELSMVKIPSRGSARYLSRKYQKSEEYIRDNFLILDIFFEALNYETIEQKKAYDIAGL 437

  Fly   383 LSNVGGVLGICIGCSFISGFELIYFLVFRLWTNYLRQ 419
            |.::||.:|:.||.|.::..|::.: ::.:..|.::|
Zfish   438 LGDIGGQMGLFIGASILTILEILDY-IYEVAKNKIKQ 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	94/475 (20%)
asic4b	NP_999951.1	ENaC	54..497	CDD:273304	94/482 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	450..452		1/1 (100%)