DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk27 and Scnn1b

DIOPT Version :10

Sequence 1:NP_647826.2 Gene:ppk27 / 38440 FlyBaseID:FBgn0035458 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_036780.1 Gene:Scnn1b / 24767 RGDID:3640 Length:638 Species:Rattus norvegicus


Alignment Length:566 Identity:108/566 - (19%)
Similarity:182/566 - (32%) Gaps:190/566 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FNKTVVEYFRKTSLNGFGLLYFIRKRRI-----QRIFWFLFISFGILFA-----SYAVFSMVLEF 62
            :.:.:|.|...|:.:|       .||.|     ::..|||..   :|||     .:.||  :..:
  Rat    22 YKELLVWYCNNTNTHG-------PKRIICEGPKKKAMWFLLT---LLFACLVCWQWGVF--IQTY 74

  Fly    63 LSYSTIADLS-ELKVLEDEIHFPELKICSGYKFSYRNMLASAHDLVSSQNKSLDYWLNKLSLLSG 126
            ||:.....|| ..|.:    :||.:.:|:...|.|..:.....||.......||..|...|..:.
  Rat    75 LSWEVSVSLSMGFKTM----NFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTN 135

  Fly   127 YFDALSVKAEN------VDDLN-----------------------------------------SL 144
            ....|:....|      :|:.|                                         ::
  Rat   136 TTSTLNFTIWNHTPLVLIDERNPDHPVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTV 200

  Fly   145 LDIKNISSFLLALTP-----------------------ACESLILKCKLNNIPANCLKLFTLKAY 186
            ...:|.:|...|:|.                       |.:.:||.|.....|.: .:.||...|
  Rat   201 CTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCS-HRNFTPIFY 264

  Fly   187 ND-GNCCV---------LRNSNLTGE--LTLFMDSSQIDEYPLNGNLPGFSLHVPSWQGRVSIN- 238
            .| |||.:         |.::|...|  |.|.:|..|.|..|...:..|..|.:...:....|. 
  Rat   265 PDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIRE 329

  Fly   239 ------PGEMAAVEIEVMELQGNSQ------LNEYAVEKRACYFSQEGE-SREKCLHECRIKATL 290
                  .|...::.:.:.:|||..:      :|...|..:..|...... |.:.|||.|.....:
  Rat   330 EGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQDHMI 394

  Fly   291 INCQCVPYPF------------EFRTQKFGYCTLENIRCLQLVERNWSPAQCPQCLPLCNQLFYR 343
            .||.|..|.:            :|....:.|.:|:    :.:|:|....:.|.:.   ||...|:
  Rat   395 HNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQ----MSVVQRETCLSMCKES---CNDTQYK 452

  Fly   344 LNKQILGHLHPWRSE-----------------------------LNFKFKTPHRQRYKT------ 373
            :...    :..|.||                             ||..|:   ...|:|      
  Rat   453 MTIS----MADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQ---EFNYRTIEESPA 510

  Fly   374 -NILYHWYQMLSNVGGVLGICIGCSFISGFELIYFLVFRLWTNYLR 418
             ||::    :|||:||..|..:|.|.:...|....::..:|...::
  Rat   511 NNIVW----LLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITVIK 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk27NP_647826.2 ASC 15..407 CDD:459966 106/546 (19%)
Scnn1bNP_036780.1 ENaC 21..621 CDD:273304 108/566 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844 614..618
Blue background indicates that the domain is not in the aligned region.

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