Protein Alignment ppk27 and Scnn1g

DIOPT Version :10

• Sequence 1: NP_647826.2
• Gene: ppk27 / 38440
• FlyBaseID: FBgn0035458
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_035456.1
• Gene: Scnn1g / 20278
• MGIID: 104695
• Length: 655
• Species: Mus musculus
• Alignment Length: 563
• Identity: 108/563 - (19%)
• Similarity: 186/563 - (33%)
• Gaps: 215/563 - (38%)

  Fly    30 IRKRRIQRIFWFLFISFGILFASYAVFSMVLEFLSYSTIADLSELKVLEDEIHFPELKIC--SGY 92
            :.:.|::|:.|   |:|.:...:..::...|...|:.|::  ..:||...::.||.:.||  :.|
Mouse    46 VSRGRLRRLLW---IAFTLTAVALIIWQCALLVFSFYTVS--VSIKVHFQKLDFPAVTICNINPY 105

  Fly    93 KFSYRNMLASAHD-----------------------------------------------LVSSQ 110
            |:|..:.|.:..|                                               ||.::
Mouse   106 KYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFLNLIPLLVFNE 170

  Fly   111 N---KSLDYWLNKLSLLSGYFDALSVKAENV----------------------------DDLNSL 144
            |   |:.|::..:...:||   .:..||.||                            ..:|::
Mouse   171 NEKGKARDFFTGRKRKISG---KIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAI 232

  Fly   145 -----LDIKNISSFL-----LALTPACESLILKCKLNNI--PANCLKLFTLKAYNDGNCCVLRNS 197
                 |...||.:.:     :.::.:.|.|::.|..:.:  .|....||....|  |||....|.
Mouse   233 QEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDARNFTLFHHPMY--GNCYTFNNR 295

  Fly   198 NLTGELTLFMDSSQI----------DEYPLNGNLPGFSLHVPSWQGRVSINPG------EMAAVE 246
            .....|:..|..|:.          |||  |..|      |.|...:|.::..      |....|
Mouse   296 ENATILSTSMGGSEYGLQVILYINEDEY--NPFL------VSSTGAKVLVHQQNEYPFIEDVGTE 352

  Fly   247 IEV-------MELQGNSQLNE-YAVEKRACYFSQEGE------------SREKCLHECRIKATLI 291
            ||.       |.|..:.:|:| |:    .|  :::|.            |.:.||:.|.....:.
Mouse   353 IETAMSTSIGMHLTESFKLSEPYS----QC--TEDGSDVPVTNIYNAAYSLQICLYSCFQTKMVE 411

  Fly   292 NCQCVPYPFEFRTQKF----GYCTLENIRCLQLVERNWSPA--QCPQ--------CLPLCNQLFY 342
            .|.|..|     :|..    .||..:.       ..||...  |..|        |..:|.|...
Mouse   412 KCGCAQY-----SQPLPPAANYCNYQQ-------HPNWMYCYYQLYQAFVREELGCQSVCKQSCS 464

  Fly   343 RLNKQILGHLHPWRSELNFKF----------KTPHRQRYKTNI--LYHWYQ-------------- 381
            .....:...|..|.||.:.|:          :..:::..||::  |..:|:
Mouse   465 FKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANS 529

  Fly   382 ---MLSNVGGVLGICIGCSFISGFELI--YFLVF------RLW 413
               :|||.||.||:.:.||.:...|:|  :|:.|      |.|
Mouse   530 IEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSIIARRQW 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk27	NP_647826.2	ASC	15..407	CDD:459966	104/549 (19%)
Scnn1g	NP_035456.1	ENaC	24..636	CDD:273304	108/563 (19%)
		Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000305|PubMed:15007080, ECO:0000305|PubMed:18650438	140..227		11/89 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..636
		PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170	629..633