DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32264 and Phactr3

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_001171262.1	Gene:	Phactr3 / 74189	MGIID:	1921439	Length:	559	Species:	Mus musculus

Alignment Length:	794	Identity:	213/794 - (26%)
Similarity:	314/794 - (39%)	Gaps:	277/794 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 QAAKDGLAINGGQCAKKQNGAAIRTNS--------------------------LGSGTRTPPLER 294
            |.|...|::|..:  .|...||:||.:                          |.||.||||:.|
Mouse     2 QTANQMLSLNFRR--MKSGTAAVRTRARHRPPGSGPSRCGDEMDQTPPARSEPLVSGIRTPPVRR 64

  Fly   295 KSKLSALGRFFKPWKWRRKKKSEKFEAASKSLERKISVRANRDELVQKGILMPESPLGNIPEPGE 359
            .|||:.|||.|||||| ||||:||.:..:.:||:|::.|..|:||:::|:|
Mouse    65 NSKLATLGRIFKPWKW-RKKKNEKLKQTTSALEKKMAGRQGREELIKQGLL-------------- 114

  Fly   360 ESYYNNSNSGATANGSLLNSAVHNNSMSQANNSINATTGNPLISAAQQQLNQGLPNSISVQQFNG 424
                           .::.....|.:.|....|      .|:
Mouse   115 ---------------EMMEQDSENKACSPKEGS------QPV----------------------- 135

  Fly   425 QNQNPQNSMANGLVGGGGGGGDGSSDTSSLSGGVPHSQSAPQQLGVGQPPPPLTPLAQHHQALAQ 489
            |::.|.                |..:|.:..|..|.|.||
Mouse   136 QSEPPA----------------GEQETLTSEGAQPGSPSA------------------------- 159

  Fly   490 QLQQRFAISNNNEPRKDKTDAQQQQHGGNGTISTPNIEQPTCQGSMLPPPGGGGHHQVDGSGKME 554
                    |..::..:|:..:..........|.:.:..:....||:||...             |
Mouse   160 --------SGTDQVSQDELLSSDAHLDDTANIPSASTAEEADAGSLLPTTD-------------E 203

  Fly   555 RPNTLAGANKLTRRGVNICYHNEHMYGEDGKMVGGPPGSTPPPYPGGKLPPGVMLSELPEPPIPL 619
            ....|||::.|                      ..||.|...           .:|:||.||:
Mouse   204 PSQALAGSDSL----------------------DSPPRSLER-----------SVSQLPSPPL-- 233

  Fly   620 SEIGPIP-PPPMFSTPSPTLIAGRP---HGPGAVNDQDYQQDYDYDDNDPD-QDELDSDDEYAPY 679
                 :| |||..|:.:...:.|:.   .||...|            |:|. :.:|.:     |.
Mouse   234 -----LPTPPPKASSKATKNVTGQAALFQGPSMKN------------NEPALRGQLAT-----PT 276

  Fly   680 GGNHV----RMMDTQRVEEIPAKEPKPNAVPLKSALKKKGGMQPASASTPVTPTQEHGAGSAATA 740
            |..||    |.:...||.|           .|..||..|             ..|:...|.....
Mouse   277 GSPHVTTVHRPLPPSRVME-----------ELHRALATK-------------HRQDSFQGRECRG 317

  Fly   741 AAMANSNGGIGSMAAAAAAAAQQSANQRPLVVRQDAAGNNYSLKPILRPRIRLCRQQMFNIQLPC 805
            :.....:      ...:..::.:...:|......|.|..|                     :...
Mouse   318 SPKKRMD------VRLSRTSSMERGKERDEAWSFDGASEN---------------------KWTA 355

  Fly   806 TVENKENARPFVIRESSSDSDDSDGHIVYRDED--NDNT---RLAKLARKESLSLKLQLRPDKQD 865
            |.:::||....::  ||...||.   ::|:||:  ||:.   .|.:..:||.|::||:.||.||:
Mouse   356 TKDSEENKENLML--SSELKDDM---LLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQE 415

  Fly   866 LINRNILHQVNDNELKESKEAIGARLIRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKSYLL 930
            |.:|||..:..|.|.:|.::.|..:|.:|||.||..|||..|||||.::...|::::.|.|..|.
Mouse   416 LEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLT 480

  Fly   931 RKLSFRPTVEELKEKKI-IRFNDYIEVTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMA 994
            |||:.||||:||:::|| |||:||:||.:|.|||||||||||||:..|||||||||||:||:||.
Mouse   481 RKLNQRPTVDELRDRKILIRFSDYVEVARAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEME 545

  Fly   995 VHEGSRHLTRFHRP 1008
            ||..|:||||||||
Mouse   546 VHASSKHLTRFHRP 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	9/21 (43%)
		RPEL	851..876	CDD:128947	12/24 (50%)
		RPEL	889..914	CDD:128947	14/24 (58%)
		RPEL	927..952	CDD:128947	15/25 (60%)
Phactr3	NP_001171262.1	RPEL	440..464	CDD:128947	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2600
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.850