DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32264 and phactr3a

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_001107883.1	Gene:	phactr3a / 556928	ZFINID:	ZDB-GENE-080220-4	Length:	498	Species:	Danio rerio

Alignment Length:	774	Identity:	200/774 - (25%)
Similarity:	288/774 - (37%)	Gaps:	295/774 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 ILHSSNAQQQQQQAAKDGLAINGGQCAKKQNGAAIRTNSLGSGTRTPPLERKSKLSALGRFFKPW 308
            :||...:|......::.|:.::.|....:|. ..:|::.|.||..|||:.|.|||:.|||.|:||
Zfish    11 LLHRGRSQSDPNILSESGIDLSHGADVIEQQ-KVLRSSCLVSGVHTPPIRRHSKLATLGRIFRPW 74

  Fly   309 KWRRKKKSEKFEAASKSLERKISVRANRDELVQKGILMPESPLGNIPEPGEESYYNNSNSGATAN 373
            || ||||:||.:.:|            .|..:..|:..|: |.|.|        ...|||.....
Zfish    75 KW-RKKKNEKLKQSS------------TDVALACGLHSPD-PSGPI--------QGLSNSEIRLP 117

  Fly   374 GSLLNSAVHNNSMSQANNSINATTGNPLISAAQQQLNQGLPNSISVQQFNGQNQNPQNSMANGLV 438
            ||                                   ||...|||..::....|:....|.:.|
Zfish   118 GS-----------------------------------QGPILSISSMEYLSSEQDNLPCMVDSL- 146

  Fly   439 GGGGGGGDGSSDTSSLSGGVPHSQSAPQQLGVGQPPPPLTPLAQHHQALAQQLQQRFAISNNNEP 503
                      .||........:.:...::..|                        .:::.|.:.
Zfish   147 ----------QDTEPTEDPKSNEEEGDEEEAV------------------------LSVNENEDV 177

  Fly   504 RKDKTDAQQQQHGGNGTISTPNIEQPTCQGSMLPPPGGGGHHQVDGSGKMERPNTLAGANKLTRR 568
            .:|:.|.::.:.......|.||     ..|::                 :.:.:|...|:|:
Zfish   178 EEDEEDQEEDEEDEEQEQSPPN-----SHGNL-----------------VSQLSTEEDADKV--- 217

  Fly   569 GVNICYHNEHMYGEDGKMVGGPPGSTPPPYPGGKLPPGVMLSELPEPPIPLSEIGPIPPPPMFST 633
                             ::...|.|.           ..:..|||..|               ..
Zfish   218 -----------------VIASVPQSN-----------SFLQKELPRVP---------------DG 239

  Fly   634 PSPTLIAGRPHGPGAVNDQDYQQDYDYDDNDPDQDELDSDDEYAPYGGN-HVRMMDTQRVEEIPA 697
            |||.::.|                                    |:.|: ||
Zfish   240 PSPVVLRG------------------------------------PFSGSPHV------------- 255

  Fly   698 KEPKPNAVPLKSALKKKGGMQPASASTPVTPT----QEHGAGSAATAAAMANSNGGIGSMAAAAA 758
                             |.:.|     |:.|:    :.|                     .|.|.
Zfish   256 -----------------GSIHP-----PLPPSCIIEELH---------------------RALAT 277

  Fly   759 AAAQQSANQRPLVVRQDAAGNNYSLKPILRPRIRLCRQQMFNIQLPCTVENKENARPFVIRESSS 823
            ...|.|..:.|       :|:..|.|.                    ..|||||.|      ...
Zfish   278 KLRQDSIEREP-------SGDGESRKE--------------------AEENKENVR------QDH 309

  Fly   824 DSDDSDGHIVYRDEDNDNT---RLAKLARKESLSLKLQLRPDKQDLINRNILHQVNDNELKESKE 885
            ...|:.|.|...|..||:.   .|.:..|||.|::||:.||.||:|.:|||....:|.|.:|.::
Zfish   310 CFTDASGIIYDIDSWNDSVISGTLPRRMRKELLAVKLRNRPSKQELEDRNIFPARSDQERQEIRQ 374

  Fly   886 AIGARLIRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKSYLLRKLSFRPTVEELKEKKI-IR 949
            .|..:|.:|||.||..|||..|||||.::...|::::.|.|..|.|||:.||||:||:|:|| ||
Zfish   375 QIEMKLAKRLSQRPAVEELESRNILKQRNDQTEQEERREIKQRLNRKLNQRPTVDELRERKILIR 439

  Fly   950 FNDYIEVTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMAVHEGSRHLTRFHRP 1008
            |:||:||.:|.|||||||||||||:..||||||||||||||:||.||..|:||||||||
Zfish   440 FSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEFKSTEMEVHASSKHLTRFHRP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	2/21 (10%)
		RPEL	851..876	CDD:128947	12/24 (50%)
		RPEL	889..914	CDD:128947	14/24 (58%)
		RPEL	927..952	CDD:128947	16/25 (64%)
phactr3a	NP_001107883.1	RPEL	379..403	CDD:128947	14/23 (61%)
phactr3a	NP_001107883.1	RPEL	417..441	CDD:128947	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580193
Domainoid	1	1.000	107	1.000	Domainoid score	I6442
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.830