DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32264 and PHACTR1

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	XP_016865941.1	Gene:	PHACTR1 / 221692	HGNCID:	20990	Length:	666	Species:	Homo sapiens

Alignment Length:	841	Identity:	257/841 - (30%)
Similarity:	345/841 - (41%)	Gaps:	298/841 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 PQRSNSMDFLNFEEKRQLIASSLSLSDILH-SSNAQQQQQQAAKDGLAINGGQCAKKQNGAAIRT 280
            |..:|::.|        :|...|. .:|.| .||..:.:.  |:|...:        :..||:|:
Human    51 PNNNNNVSF--------VIHCQLG-KEIKHICSNCSRGED--ARDAEEV--------ERLAAMRS 96

  Fly   281 NSLGSGTRTPPLERKSKLSALGRFFKPWKWRRKKKSEKFEAASKSLERKISVRANRDELVQKGIL 345
            :||..||.|||:.|:||.:.|||.|||||| ||||||||:..|.:||||||:|.:|:||:::|:|
Human    97 DSLVPGTHTPPIRRRSKFANLGRIFKPWKW-RKKKSEKFKHTSAALERKISMRQSREELIKRGVL 160

  Fly   346 MPESPLGNIPEPGEESYYNNSNSGATANGSLLNSAVHNNSMSQANNSINATTGNPLISAAQQQLN 410
            ..     ...:.||.|..|..:|  ..||         .|:|.:..|:      |.:|..:....
Human   161 KE-----IYDKDGELSISNEEDS--LENG---------QSLSSSQLSL------PALSEMEPVPM 203

  Fly   411 QGLPNSISVQQFNGQNQNPQNSMANGLVGGGGGGGDGSSDTSSLSGGVPHSQSAP--QQLGV--G 471
            ...|.|..|.|       |.:.|            ||           |.|:.:|  .:.||  .
Human   204 PRDPCSYEVLQ-------PSDIM------------DG-----------PVSEESPSASESGVLLS 238

  Fly   472 QPP--------PPLTPLA---QHHQALAQQLQQRFAISNNNEPRKDKTDAQQQQHGGNGTISTPN 525
            |.|        ||..|.|   .|.:...:||                                |.
Human   239 QDPSAKPVLLLPPKKPAAFPGDHEETPVKQL--------------------------------PL 271

  Fly   526 IEQPTCQGSMLPPPGGGGHHQVDGSGKMERPNTLAGANKLTRRGVNICYHNEHMYGEDGKMVGGP 590
            ::||..    |||                :|.|.. ||.||..|..:
Human   272 LKQPPA----LPP----------------KPTTRI-ANHLTDPGAPV------------------ 297

  Fly   591 PGSTPPPYPGGKLPPGVMLSELPEPPIPLSEIGPIPPPPMFSTPSPTLIAGRPHGPGAVNDQDYQ 655
                                :||..|:.||     ||.|    |...:|.
Human   298 --------------------KLPCLPVKLS-----PPLP----PKKVMIC--------------- 318

  Fly   656 QDYDYDDNDPDQDELDSDDEYAPYGGNHVRMMDTQRVEEIPAKEPKPNAVPLKSALKKKGGMQPA 720
                                 .|.||                    |:...:....:|.|....|
Human   319 ---------------------MPVGG--------------------PDLSLVSYTAQKSGQQGVA 342

  Fly   721 SASTPVTPTQ--------EHGAGSAATAAAMANSNGG---IGSMAAAAAAAAQ--QSANQR-PLV 771
            .....|.|:|        .||....:|..::.....|   |..:....|...|  :|:.|| |..
Human   343 QHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCS 407

  Fly   772 VRQDAAGNN-----YSLKPILRPRIRLCRQQMFNIQLPCTV----ENKENARPFVIRESSSDSDD 827
            ....::|.:     ....|:..|.||         |:|..|    :||||.        ..:||.
Human   408 TSYHSSGLHSGDGVTKAGPMGLPEIR---------QVPTVVIECDDNKENV--------PHESDY 455

  Fly   828 SDGHIVY--------RDEDNDN----TRLA-KLARKESLSLKLQLRPDKQDLINRNILHQVNDNE 879
            .|...:|        .|||:|:    :.|| |:.||:||::||..||.|::|..:|||.:..|.|
Human   456 EDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEE 520

  Fly   880 LKESKEAIGARLIRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKSYLLRKLSFRPTVEELKE 944
            ..|.::.||.:|.||||.|||||||.:|||||.::..||:::|.|.|..|.||||.|||||||:|
Human   521 RLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRE 585

  Fly   945 KKI-IRFNDYIEVTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMAVHEGSRHLTR 1004
            :|| |||:||:||..|.||||||||||||||..||||||||||||||:||.|||.||||||
Human   586 RKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTR 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	12/21 (57%)
		RPEL	851..876	CDD:128947	11/24 (46%)
		RPEL	889..914	CDD:128947	17/24 (71%)
		RPEL	927..952	CDD:128947	18/25 (72%)
PHACTR1	XP_016865941.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146554
Domainoid	1	1.000	104	1.000	Domainoid score	I6698
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40728
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	1	1.000	-	-		X711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.920