DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32264 and Phactr1

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	XP_006516968.1	Gene:	Phactr1 / 218194	MGIID:	2659021	Length:	649	Species:	Mus musculus

Alignment Length:	837	Identity:	257/837 - (30%)
Similarity:	348/837 - (41%)	Gaps:	295/837 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 LIASSLSLSDI----LHSSNAQQQQQQAAKDGLAINGGQCAKKQNGAAIRTNSLGSGTRTPPLER 294
            |:|:| |..||    :....::......|:..::.|.|...:.:..||:|::||..||.|||:.|
Mouse    46 LMAAS-SEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRR 109

  Fly   295 KSKLSALGRFFKPWKWRRKKKSEKFEAASKSLERKISVRANRDELVQKGILMPESPLGNIPEPGE 359
            :||.:.|||.|||||| ||||||||:..|.:||||||:|.:|:||:::|:|..     ...:.||
Mouse   110 RSKFANLGRIFKPWKW-RKKKSEKFKHTSAALERKISMRQSREELIKRGVLKE-----IYDKDGE 168

  Fly   360 ESYYNNSNSGATANGSLLNSAVHNNSMSQANNSINATTGNPLISAAQQQLNQGLPNSISVQQFNG 424
            .|..|..:|  ..||         .|:|.:..|:      |.:|..:.......|.|..|.|.:.
Mouse   169 LSISNEDDS--LENG---------QSLSSSQLSL------PALSEMEPVPMPRDPCSYEVLQASD 216

  Fly   425 ------QNQNPQNSMANGLVGGGGGGGDGSSDTSS---------LSGGVP--HSQSAPQQLGVGQ 472
                  ..::|..|.:..|:         |.|.|:         .|...|  |.::..:||.:.:
Mouse   217 IMDGPVSEESPSASESGVLL---------SQDPSAKPVLFLPPKKSAAFPGDHEETPVKQLSLHK 272

  Fly   473 PPPPLTPLAQHHQALAQQLQQRFAISNNNEPRKDKTDAQQQQHGGNGTISTPN--IEQPTCQGSM 535
            .||.|.|                           |..|:...|     ::.|.  ::.|.....:
Mouse   273 QPPALPP---------------------------KPTARIANH-----LTDPGAPVKLPCLPVKL 305

  Fly   536 LPP----------PGGGGHHQVDGSGKMERPN-TLA--GANKLTRRGVNICYHN------EH--M 579
            .||          |.||             |. |||  .|.|.:::.|...:|.      :|  .
Mouse   306 SPPLPPKKVLICMPVGG-------------PELTLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQ 357

  Fly   580 YGEDGKMVGGPPGSTPPPYPGGKLPPGVMLSELPEPPIPLSEIGPIPPPPMFSTPSPTLIAGRPH 644
            ||..|:.:   |.||      |.||.                                    .|.
Mouse   358 YGSHGQHL---PSST------GTLPM------------------------------------HPS 377

  Fly   645 GPGAVNDQDYQQDYDYDDNDPDQDELDSDDEYAPYGGNHVRMMDTQRVEEIPAKEPKPNAVPLKS 709
            |...:                  |||           |....|..||:|....:.|
Mouse   378 GCRMI------------------DEL-----------NKTLAMTMQRLESSEQRVP--------- 404

  Fly   710 ALKKKGGMQPASASTPVTPTQEHGAGSAATAAAMANSNGGIGSMAAAAAAAAQQSANQRPLVVRQ 774
                             ..|..|.:|        .:|:.||
Mouse   405 -----------------CSTSYHSSG--------LHSSDGI------------------------ 420

  Fly   775 DAAGNNYSLKPILRPRIRLCRQQMFNIQLPCTV----ENKENARPFVIRESSSDSDDSDGHIVY- 834
            ..||      |:..|.||         |:|..|    :||||.        ..:.|..|...:|
Mouse   421 TKAG------PMGLPEIR---------QVPTVVIECDDNKENV--------PHEPDYEDSPCLYG 462

  Fly   835 -------RDEDND----NTRLA-KLARKESLSLKLQLRPDKQDLINRNILHQVNDNELKESKEAI 887
                   .|||:|    .:.|| |:.||:||::||..||.|::|..:|||.:..|.|..|.::.|
Mouse   463 REEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQI 527

  Fly   888 GARLIRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKSYLLRKLSFRPTVEELKEKKI-IRFN 951
            |.:|.||||.|||||||.:|||||.::..||:::|.|.|..|.||||.|||||||:|:|| |||:
Mouse   528 GTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFS 592

  Fly   952 DYIEVTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMAVHEGSRHLTRFHRP 1008
            ||:||..|.||||||||||||||..||||||||||||||:||.|||.||||||||||
Mouse   593 DYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	12/21 (57%)
		RPEL	851..876	CDD:128947	11/24 (46%)
		RPEL	889..914	CDD:128947	17/24 (71%)
		RPEL	927..952	CDD:128947	18/25 (72%)
Phactr1	XP_006516968.1	RPEL	140..161	CDD:367165	12/20 (60%)
		RPEL	491..515	CDD:128947	11/23 (48%)
		RPEL	530..554	CDD:128947	17/23 (74%)
		RPEL	567..592	CDD:128947	17/24 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2600
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	1	1.000	-	-		X711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.880