DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32264 and Phactr2

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	XP_006512736.1	Gene:	Phactr2 / 215789	MGIID:	2446138	Length:	706	Species:	Mus musculus

Alignment Length:	938	Identity:	244/938 - (26%)
Similarity:	361/938 - (38%)	Gaps:	339/938 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 PDLTDGIDHPSAQAATP---------------PDSPNAQSTGPSDLEQQLCVVAKMQKSVTITVT 216
            ||...|.:..:|:|..|               |..|:.:....|||..
Mouse    12 PDQPAGQEAAAAEALDPEPEAPGPPVPSLRWLPGDPSPRGRSQSDLSS----------------- 59

  Fly   217 PQRSNSMDFLNFEEKRQLIASSLSLSDILHSSNAQQQQQQAAKDGLAINGGQCAKKQNGAAIRTN 281
                               |||......:|.|        .:.|||           :.|:| .|
Mouse    60 -------------------ASSRGRPLRVHIS--------GSVDGL-----------DKASI-AN 85

  Fly   282 SLG--SGTRTPPLERKSKLSALGRFFKPWKWRRKKKSEKFEAASKSLERKISVRANRDELVQKGI 344
            |.|  :|::|||.:||.|||.:|:.|||||||:||.|:||...|..||||||.|.:|:||:::|:
Mouse    86 SDGPPAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERKISTRQSREELIRRGL 150

  Fly   345 LMPESPLGNIPEPGEESYYNNSNSGATANGSLLNSAVHNNSMSQANNSINATTGNPLISAAQQQL 409
            |.      .:|:...:...|..||    ||.:::                      :...|.|:.
Mouse   151 LK------ELPDQDGDVTVNFENS----NGHMIH----------------------IGEEATQEE 183

  Fly   410 NQGLP--NSISV--------QQFNGQNQN--------------------------PQNSMANGLV 438
            |.|.|  .|.||        :|...:.:|                          |:.|
Mouse   184 NVGKPEEGSDSVCEKTPPREEQAEEKTENTEIHSEPTAAPTLPPTAPPKPKPKPKPKKS------ 242

  Fly   439 GGGGGGGDGSSDTSSLSGG-VPHSQSAPQQLGVGQPPPPLTPLAQH--HQALAQQLQQRFAISNN 500
               .|...|::..:|..|. ||.::...:......|.||..|.:::  .:|.|.:       :.:
Mouse   243 ---PGPPKGATAAASHKGDEVPPNRKNVKAPSKQAPTPPPKPTSRNTSREAAASR-------AGS 297

  Fly   501 NEPRKDKTDAQQQQHGGNGTISTPNIEQPTCQG--------------------SMLPP------- 538
            :.|:|............:.|.|.|...:.:..|                    |.|.|
Mouse   298 SHPKKATGSKASASPSTSSTSSRPRAPKESLAGKAGLVGTTRGKKKISKQPVASRLSPSTTTSDT 362

  Fly   539 PGGGGHHQVDGSGKMERPNTLAGANKLTRRGVNICYHNEHMYGEDGKMVGGPPGSTPPPYPGGKL 603
            |...|.....|...:....|:|||             .|....:....:..||.:.||..|...|
Mouse   363 PSLKGELSDTGIESLTPEETVAGA-------------EEQATSKSKAAIALPPSTAPPSPPALLL 414

  Fly   604 PPGVMLSELPEPPIPLSEIGPIPPPPMFSTPSPTLIAGRPHGPGAVNDQDYQQDYDYDDNDPDQD 668
            ||....:...:.|:.|...||..|
Mouse   415 PPEDQCTIALDTPMVLVSDGPTLP----------------------------------------- 438

  Fly   669 ELDSDDEYAPYGGNHVRMMDTQRV---EEIPAKEPKPNAVPLKSALKKKGGMQPASASTPVTPTQ 730
                           |..:||.::   ||                        |:|.::|.:.|
Mouse   439 ---------------VSALDTSQLLWTEE------------------------PSSRTSPYSST- 463

  Fly   731 EHGAGSAATAAAMANSNGGIGSMAAAAAAAAQQSANQRPLVVRQDAAGNNYSLKPILRPRIRLCR 795
              |.|.:...|....:...:|                 |.::.....|::
Mouse   464 --GLGGSREQAKCFTTKDELG-----------------PQLLTPGQMGDS--------------- 494

  Fly   796 QQMFNIQLPCTVENKENARPFVIRESSSDSDDSDGHIVYRDEDN----------DNTRLAKLARK 850
            .:.|:.        .|:..|   ||..::..||||.|:|.|:|:          ::...:|:.|:
Mouse   495 SESFSA--------PEDEAP---REYQANDSDSDGPILYTDDDDEEDDDDDSSGESALASKIRRR 548

  Fly   851 ESLSLKLQLRPDKQDLINRNILHQVNDNELKESKEAIGARLIRRLSMRPTAEELVERNILKTQSP 915
            ::|::||..||.|::|.::|||.:.::.|.:|.::.||.:|:||||.|||.|||.:|||||.::.
Mouse   549 DTLAIKLGNRPSKKELEDKNILQRTSEEERQELRQQIGTKLVRRLSQRPTTEELEQRNILKQKNE 613

  Fly   916 AEEKKQKEEKKSYLLRKLSFRPTVEELKEKKIIRFNDYIEVTQAHDYDRRADKPWTRLTPKDKAA 980
            .||::.|.|.|..|.||||.||||.||:.::|:|||:|:|||.:.||||||||||.||||.||||
Mouse   614 EEEQEAKMELKRRLSRKLSLRPTVAELQARRILRFNEYVEVTDSPDYDRRADKPWARLTPADKAA 678

  Fly   981 IRKELNEFKSSEMAVHEGSRHLTRFHRP 1008
            ||||||||||:||.|||.||..||||||
Mouse   679 IRKELNEFKSTEMEVHEESRQFTRFHRP 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	12/21 (57%)
		RPEL	851..876	CDD:128947	10/24 (42%)
		RPEL	889..914	CDD:128947	16/24 (67%)
		RPEL	927..952	CDD:128947	14/24 (58%)
Phactr2	XP_006512736.1	RPEL	132..153	CDD:367165	12/26 (46%)
		RPEL	549..574	CDD:128947	10/24 (42%)
		RPEL	588..612	CDD:128947	16/23 (70%)
		RPEL	625..650	CDD:128947	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836655
Domainoid	1	1.000	104	1.000	Domainoid score	I6702
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2600
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006405
OrthoInspector	1	1.000	-	-		otm42801
orthoMCL	1	0.900	-	-		OOG6_108169
Panther	1	1.100	-	-	LDO	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	1	1.000	-	-		X711
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780