DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32264 and phactr1

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	NP_001340862.1	Gene:	phactr1 / 100334776	ZFINID:	ZDB-GENE-101230-3	Length:	541	Species:	Danio rerio

Alignment Length:	898	Identity:	239/898 - (26%)
Similarity:	337/898 - (37%)	Gaps:	411/898 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQLQLPPPDLTDGIDHPSAQAATPPDSP---NAQSTGPSDLEQQLCVVAKMQKSVTITVTPQRSN 221
            :.:..|...:||  .|.|| ||.|...|   .|..|                     .:||:.:
Zfish     6 RSISAPSRGVTD--RHGSA-AAAPMAGPAFTGAHGT---------------------WITPRLT- 45

  Fly   222 SMDFLNFEEKRQLIASSLSLSDILHSSNAQQQQQQAA---------------KDGLAING----- 266
                     .|:..:||.|||.   ||:|::.:::.|               .....|:|
Zfish    46 ---------LREDASSSSSLSS---SSSAEKPRKRRAFNLVKLRQPTAPGNNNTPFVISGHIKHI 98

  Fly   267 -GQCAK---------KQNGAAIRTNSLGSGTRTPPLERKSKLSALGRFFKPWKWRRKKKSEKFEA 321
             ..|::         .:..||:|::||..||.|||:.|:|||::|||.|||||| |||||:||:.
Zfish    99 CSNCSRGNDIRDAEGAERLAAMRSDSLVPGTHTPPIRRRSKLASLGRLFKPWKW-RKKKSDKFKQ 162

  Fly   322 ASKSLERKISVRANRDELVQKGILMPESPLGNIPEPGEESYYNNSNSGATAN---GSLLNSAVHN 383
            .|..||||:|:|.:|:||:::|:|             :|.|..:..||.:|.   ..|....|.:
Zfish   163 TSAVLERKMSMRQSREELIKRGVL-------------KEVYEKDEVSGDSARVCVSDLERQTVLS 214

  Fly   384 NSMSQANNSINATTGNPLISAAQQQLN-QGLPNSISVQQFNGQNQNPQNSMANGLVGGGGGGGDG 447
            .....|.:|:.||     :|.::.|.: :|||
Zfish   215 PVSESAESSVTAT-----VSFSEVQSSAEGLP--------------------------------- 241

  Fly   448 SSDTSSLSGGVPHSQSAPQQLGVGQPPPPLTPLAQHHQALAQQLQQRFAISNNNEPRKDKTDAQQ 512
                 .||..||..         .|.|||:.||                          ::|:..
Zfish   242 -----CLSDLVPKP---------SQAPPPVKPL--------------------------QSDSAD 266

  Fly   513 QQHGGNGTISTPNIEQPTCQGSMLPPPGGGGHHQVDGSGKMERPNTLAGANKLTRRGVNICYHNE 577
            ..|     :..|:::|
Zfish   267 ISH-----VRPPSLKQ------------------------------------------------- 277

  Fly   578 HMYGEDGKMVGGPPGSTPPPYPGGKLPPGVMLSELP-----EPPIPLSEIGPIPPPPMFSTPSPT 637
                        ||...|.||           |.:|     :...||:|.|
Zfish   278 ------------PPALPPKPY-----------SRIPNHLTGDTHSPLAESG-------------- 305

  Fly   638 LIAGRPHGPGAVNDQDYQQDYDYDDNDPDQDELDSDDEYAPYGGNHVRMMDTQRVEEIPA----- 697
             :||.  .||:|                                          ::.:|:
Zfish   306 -VAGL--SPGSV------------------------------------------LQAVPSVLMET 325

  Fly   698 KEPKPNAVPLKSALKKKGGMQPASASTPVTPTQEHGAGSAATAAAMANSNGGIGSMAAAAAAAAQ 762
            :|.|.|                                                          :
Zfish   326 EEEKEN----------------------------------------------------------R 332

  Fly   763 QSANQRPLVVRQDAAGNNYSLKPILRPRIRLCRQQMFNIQLPCTVENKENARPFVIRESSSDSDD 827
            :|.:|.|.|.      :.::|.                            ...|..||...:.::
Zfish   333 ESLHQTPAVT------HTHTLV----------------------------THTFSTREEEDEEEE 363

  Fly   828 SDGHIVYRDEDNDNTRLA-KLARKESLSLKLQLRPDKQDLINRNILHQVNDNELKESKEAIGARL 891
            .|.     ||....:.|| ::.||:||::||..||.|::|.::|||..::|.|..||::.||.:|
Zfish   364 EDD-----DESLFTSTLALRILRKDSLAIKLSNRPSKRELEDKNILPMMSDQERLESRQQIGTKL 423

  Fly   892 IRRLSMRPTAEELVERNILKTQSPAEEKKQKEEKKSYLLRKLSFRPTVEELKEKKI-IRFNDYIE 955
            .||||.||:||||.:|||||.::..||.::|.|.|..|.||||.|||||||:|.|| |||:||:|
Zfish   424 TRRLSQRPSAEELEQRNILKPRNEQEELEEKRELKKRLSRKLSQRPTVEELREAKILIRFSDYVE 488

  Fly   956 VTQAHDYDRRADKPWTRLTPKDKAAIRKELNEFKSSEMAVHEGSRHLTRFHRP 1008
            |.:|.||||||||||||||..|||||||||||||||||.|||.||||||||||
Zfish   489 VAEAQDYDRRADKPWTRLTAADKAAIRKELNEFKSSEMEVHESSRHLTRFHRP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	11/21 (52%)
		RPEL	851..876	CDD:128947	11/24 (46%)
		RPEL	889..914	CDD:128947	16/24 (67%)
		RPEL	927..952	CDD:128947	18/25 (72%)
phactr1	NP_001340862.1	RPEL	166..188	CDD:308408	11/34 (32%)
		Herpes_BLLF1	<213..>305	CDD:330317	33/246 (13%)
		RPEL	384..405	CDD:308408	10/20 (50%)
		RPEL	422..446	CDD:128947	16/23 (70%)
		RPEL	462..484	CDD:128947	16/21 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580188
Domainoid	1	1.000	107	1.000	Domainoid score	I6442
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I2614
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto39970
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	1	1.000	-	-		X711
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.020