DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32264 and Phactr4

DIOPT Version :9

Sequence 1:	NP_728897.1	Gene:	CG32264 / 38438	FlyBaseID:	FBgn0052264	Length:	1008	Species:	Drosophila melanogaster
Sequence 2:	XP_006538519.1	Gene:	Phactr4 / 100169	MGIID:	2140327	Length:	704	Species:	Mus musculus

Alignment Length:	811	Identity:	253/811 - (31%)
Similarity:	352/811 - (43%)	Gaps:	219/811 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 NSLGSGTRTPPLERKSKLSALGRFFKPWKWRRKKKSEKFEAASKSLERKISVRANRDELVQKGIL 345
            :|:.:|..|||.:||||.||||:.|||||||:||.|:||:..|:.||||||:|..|:|||::|:|
Mouse    30 DSVEAGDTTPPTKRKSKFSALGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVL 94

  Fly   346 MPESPLGNIPEPGEESYYNNSNSGATANGSLLNS-----------AVHNNSMSQANNSINATTGN 399
            : |.|..:..:.|:.|:....|...|..||..:|           ::.|.:..:.:.....:||:
Mouse    95 L-EDPEQDGEDSGKLSHAALKNGHTTPIGSARSSSPVLVEEEPERSLRNLTPEEESKKRLGSTGS 158

  Fly   400 PLISAAQ--------QQLNQGLPNSISVQQFNGQNQNPQNSMANGLVGGGG----------GGGD 446
            ...|.|:        |.|   ||....:.......:.|..|.|..:....|          ...|
Mouse   159 QPNSEAEPGPEHAPKQPL---LPPKRPLSSSCEAKEVPAGSTARSVSSTSGSTTVTSAATTAATD 220

  Fly   447 GSSDTSSLSGGVPHSQSAPQQLGVG---------------QPP-PPLTPLAQHHQALAQQLQQRF 495
            .:....|..|..|....||:.|...               ||| ||..|..::...:..:|.|..
Mouse   221 MTKTVKSFVGPTPAPAPAPRTLPAAPASANTAATTTAPAKQPPIPPPKPAQRNSNPIIAELSQAM 285

  Fly   496 AISNNNEPRKDKTDAQQQQHGGNGTISTPNIEQPTCQGSMLPPPGGGGHHQVDGSGKMERPNTLA 560
                                 .:||:    :.:|:   ..|||..|.....:. |.:.....|..
Mouse   286 ---------------------NSGTV----LSKPS---PPLPPKRGIPSTSIP-SLEPAASFTTK 321

  Fly   561 GANKLTRRGVNICYHNEHMYGEDGKMVGGPPGSTPPPYPGGKLPPGVMLSELPEPPIPLSEIGPI 625
            .||....:.|::|.       |...::  ||.|..||.| ..:||     |.|..|:..::...|
Mouse   322 TANDQREKTVSLCL-------EPPLII--PPSSPSPPLP-THIPP-----EPPRSPLVPAKTFQI 371

  Fly   626 PPPPMFSTPSPTLIAGRPHGPGAVNDQDYQQDYDYDDNDPD--QDELDSDDEYAPYGGNHVRMMD 688
            .|...||:.|...             ||..|..|.....|.  ||:        .:|.:|
Mouse   372 VPEVEFSSSSDLF-------------QDISQQEDQKTEVPKKIQDQ--------SFGESH----- 410

  Fly   689 TQRVEEIPAKEPKPNAVPLKSALKKKGGMQPASASTPVTPTQE--HGAGSA--ATAAAMANSNGG 749
                  ||::.|   .:||...::     |..::..||||..|  |.|.|.  ..:.:.:...|.
Mouse   411 ------IPSRLP---PLPLHIRIQ-----QALTSPLPVTPPLEGTHRAHSLLFENSDSFSEDTGT 461

  Fly   750 IGSMAAAAAAAAQQSANQRPLVVRQDAAGNNYSLKPILRPRIRLCRQQMFNIQLPCTV------- 807
            :|                                      |.|         .||.|:
Mouse   462 LG--------------------------------------RTR---------SLPITIEMLKVPD 479

  Fly   808 -ENKENARPFV---------------IRESSSDSD-DSDGHIVYRDE----DNDNTRLAKLA--- 848
             |.:|...|||               :||...:|| ||:|.|.||||    |:|.:..:.||
Mouse   480 DEEEEQTCPFVEDVTSTSATPSLPLCLREEEKESDSDSEGPIKYRDEEEDDDDDESHQSALANRV 544

  Fly   849 -RKESLSLKLQLRPDKQDLINRNILHQVNDNELKESKEAIGARLIRRLSMRPTAEELVERNILKT 912
             ||::|::||..||.:.: .|.|...:.:..|..|.:..||..||||||.|||||||.:||||:.
Mouse   545 KRKDTLAMKLSSRPSEPE-TNLNSWPRKSKEEWNEIRHQIGNTLIRRLSQRPTAEELEQRNILQP 608

  Fly   913 QSPAEEKKQKEEKKSYLLRKLSFRPTVEELKEKKIIRFNDYIEVTQAHDYDRRADKPWTRLTPKD 977
            ::.|:.:.:|.|.|..|.||||.||||.||..:||:|||:|:|||.|||||||||||||:|||.|
Mouse   609 KNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAHDYDRRADKPWTKLTPAD 673

  Fly   978 KAAIRKELNEFKSSEMAVHEGSRHLTRFHRP 1008
            ||||||||||||||||.||..|:|.||:|||
Mouse   674 KAAIRKELNEFKSSEMEVHVDSKHFTRYHRP 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32264	NP_728897.1	RPEL	325..347	CDD:280851	13/21 (62%)
		RPEL	851..876	CDD:128947	7/24 (29%)
		RPEL	889..914	CDD:128947	17/24 (71%)
		RPEL	927..952	CDD:128947	15/24 (63%)
Phactr4	XP_006538519.1	RPEL	75..97	CDD:367165	13/22 (59%)
		RPEL	586..610	CDD:128947	17/23 (74%)
		RPEL	623..648	CDD:128947	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836656
Domainoid	1	1.000	104	1.000	Domainoid score	I6702
eggNOG	1	0.900	-	-		E1_KOG4339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42801
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12751
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3634
SonicParanoid	1	1.000	-	-		X711
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.830