DRSC/TRiP Functional Genomics Resources

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Protein Alignment dar1 and KLF4

DIOPT Version :9

Sequence 1:NP_001097493.1 Gene:dar1 / 38436 FlyBaseID:FBgn0263239 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001300981.1 Gene:KLF4 / 9314 HGNCID:6348 Length:513 Species:Homo sapiens


Alignment Length:651 Identity:174/651 - (26%)
Similarity:237/651 - (36%) Gaps:178/651 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 GESGASEAWPHLPAPSYASDVPHAQQQQLQPAGSPNSNSNGAYG----CAPLYDGAPYEVA---- 186
            |||..:.:...||:.|..:..|..:::.|:.||:||:.......    ..|:..|.||::|    
Human     6 GESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATV 70

  Fly   187 ---LGYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVLWDDITTSIQNIDPEN-A 247
               |..|||..|..|    |:...|...:.:|  :.|.||        .|.|.::.....||: |
Human    71 ATDLESGGAGAACGG----SNLAPLPRRETEE--FNDLLD--------LDFILSNSLTHPPESVA 121

  Fly   248 LMLSSSGSSNNNGSSNSSSNTGESATSQL---------PQVKMEAIDESLL--ETFSTPLLSPLE 301
            ..:|||.|::::.|.:||......:|...         |.|........||  ...:.|..:|..
Human   122 ATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFN 186

  Fly   302 IKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHYQQHYQQQHLYQHHPS--LALPGLP 364
            :                                              ..:....||  .....|.
Human   187 L----------------------------------------------ADINDVSPSGGFVAELLR 205

  Fly   365 PAVDVVELQLQQQHQQQQHLQHNNSSSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGGYLNGS 429
            |.:|.|.:..||.......|.......:|  |:.||...|:.|         ::|.|.|      
Human   206 PELDPVYIPPQQPQPPGGGLMGKFVLKAS--LSAPGSEYGSPS---------VISVSKG------ 253

  Fly   430 SSNSYGYSWHSSQSFH----TKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCP 490
                      |....|    ..|...||.........|.::.| .|||........:......  
Human   254 ----------SPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCT-HLGAGPPLSNGHRPAAHDF-- 305

  Fly   491 PAAPSTPSTSSSSISSSSA-SSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPY 554
            |.....||.::.::..... ||...|..:|  .||...| .||.:.   .:....|.:...||.:
Human   306 PLGRQLPSRTTPTLGLEEVLSSRDCHPALP--LPPGFHP-HPGPNY---PSFLPDQMQPQVPPLH 364

  Fly   555 QQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTT----LTPASAIQQQQQQPQQQQVPQQQPPP 615
            .||...|.:           |..|....|.....|    |||.|:       |.:...|....|.
Human   365 YQGQSRGFV-----------ARAGEPCVCWPHFGTHGMMLTPPSS-------PLELMPPGSCMPE 411

  Fly   616 TPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSH 680
            .|:.    :|||.|..:..||.|.                          ||:.||.|.||||||
Human   412 EPKP----KRGRRSWPRKRTATHT--------------------------CDYAGCGKTYTKSSH 446

  Fly   681 LKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKR 745
            ||||.|.|||||||.|.|..|.|:||||||||||||||||.:||:|..|:|:|:|||||||||||
Human   447 LKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKR 511

  Fly   746 H 746
            |
Human   512 H 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dar1NP_001097493.1 COG5048 641..>724 CDD:227381 43/82 (52%)
C2H2 Zn finger 671..688 CDD:275368 13/16 (81%)
zf-H2C2_2 680..707 CDD:290200 18/26 (69%)
C2H2 Zn finger 696..718 CDD:275368 16/21 (76%)
zf-H2C2_2 710..735 CDD:290200 17/24 (71%)
C2H2 Zn finger 726..746 CDD:275368 14/19 (74%)
KLF4NP_001300981.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..45 6/22 (27%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 101..109 4/15 (27%)
Interaction with ZNF296. /evidence=ECO:0000250|UniProtKB:Q60793 416..513 68/123 (55%)
COG5048 <425..508 CDD:227381 58/108 (54%)
zf-C2H2 430..454 CDD:278523 17/49 (35%)
C2H2 Zn finger 432..454 CDD:275368 16/21 (76%)
C2H2 Zn finger 462..484 CDD:275368 16/21 (76%)
Interaction with target DNA. /evidence=ECO:0000250 473..504 22/30 (73%)
zf-H2C2_2 476..501 CDD:290200 17/24 (71%)
C2H2 Zn finger 492..512 CDD:275368 14/19 (74%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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