DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and SWI5

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_010430.1	Gene:	SWI5 / 851724	SGDID:	S000002553	Length:	709	Species:	Saccharomyces cerevisiae

Alignment Length:	676	Identity:	144/676 - (21%)
Similarity:	244/676 - (36%)	Gaps:	169/676 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 SNSNGAYGCAPLYDGAPYEVALGYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPV 230
            ||:.|:...:...:|....:|....|.::....|.|:   |.:....|...|...||.|.....|
Yeast    27 SNARGSDPSSYAIEGEYKTLATDDLGNILNLNYGETN---EVIMNEINDLNLPLGPLSDEKSVKV 88

  Fly   231 L---------WDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGESAT-SQLP-QVKMEAI 284
            .         |..:...::|...|  :.|:::...|.|..:..|..|....| |..| ..|..::
Yeast    89 STFSELIGNDWQSMNFDLENNSRE--VTLNATSLLNENRLNQDSGMTVYQKTMSDKPHDEKKISM 151

  Fly   285 DESLLETFSTPLLSPLEIKT-------EKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHY 342
            .::||.|     ::..||..       |...:|||...:|.:.||:..::...:..|.||:||..
Yeast   152 ADNLLST-----INKSEINKGFDRNLGELLLQQQQELREQLRAQQEANKKLELELKQTQYKQQQL 211

  Fly   343 QQHYQQQHLYQHHPSLALP--GLPPAVDVVELQLQQQHQQQQHLQHNNSSSSSPKLATPGDNSGN 405
            |...:.    ...|....|  .:.||              .::::...::|.||.::.|..|:..
Yeast   212 QATLEN----SDGPQFLSPKRKISPA--------------SENVEDVYANSLSPMISPPMSNTSF 258

  Fly   406 TSS-----YQQQYASQLVSGSG-----------GGYLNGS--SSNSYGYSWHSSQSFHTKY--QI 450
            |.|     .:|:|..|..:.||           .|: |.|  |......:.:.:.|..||:  ..
Yeast   259 TGSPSRRNNRQKYCLQRKNSSGTVGPLCFQELNEGF-NDSLISPKKIRSNPNENLSSKTKFITPF 322

  Fly   451 HPPSAAASATA-SATATPT-----AQLGAQQQQQQQQQQQL------------------------ 485
            .|.|..:|||: ||..||.     .::..:.|:.:..::.|
Yeast   323 TPKSRVSSATSNSANITPNNLRLDFKINVEDQESEYSEKPLGLGIELLGKPGPSPTKSVSLKSAS 387

  Fly   486 ---QQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRR 547
               ....|.:..:|||.:..|:|||         ::...||..........|..|....||
Yeast   388 VDIMPTIPGSVNNTPSVNKVSLSSS---------YIDQYTPRGKQLHFSSISENALGINAA---- 439

  Fly   548 TTP---PPPYQQGHVMGLINP-PPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQV 608
             ||   ||..|..|..|:.|. .|.:                 ||..|.......::.:|:.:.|
Yeast   440 -TPHLKPPSQQARHREGVFNDLDPNV-----------------LTKNTDNEGDDNEENEPESRFV 486

  Fly   609 PQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRI---------- 663
            ..:.|.|..:|     :.::....|....||..:.:..|      |:|....|::
Yeast   487 ISETPSPVLKS-----QSKYEGRSPQFGTHIKEINTYTT------NSPSKITRKLTTLPRGSIDK 540

  Fly   664 ---------HHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHT 719
                     ..|.|.||:|.:.:..::::|.:.|..::||:|..|.|:..|.|:.:|.||.:.|.
Yeast   541 YVKEMPDKTFECLFPGCTKTFKRRYNIRSHIQTHLEDRPYSCDHPGCDKAFVRNHDLIRHKKSHQ 605

  Fly   720 GAKPFKCIVCERSFARSDHLALHMKR 745
             .|.:.| .|.:.|.|.|.|.:|..|
Yeast   606 -EKAYAC-PCGKKFNREDALVVHRSR 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	23/101 (23%)
		C2H2 Zn finger	671..688	CDD:275368	3/16 (19%)
		zf-H2C2_2	680..707	CDD:290200	8/26 (31%)
		C2H2 Zn finger	696..718	CDD:275368	8/21 (38%)
		zf-H2C2_2	710..735	CDD:290200	8/24 (33%)
		C2H2 Zn finger	726..746	CDD:275368	8/20 (40%)
SWI5	NP_010430.1	COG5048	124..630	CDD:227381	124/574 (22%)
		C2H2 Zn finger	552..574	CDD:275368	6/21 (29%)
		C2H2 Zn finger	582..604	CDD:275368	8/21 (38%)
		C2H2 Zn finger	611..627	CDD:275368	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030