DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and ACE2

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_013232.1	Gene:	ACE2 / 850822	SGDID:	S000004121	Length:	770	Species:	Saccharomyces cerevisiae

Alignment Length:	665	Identity:	126/665 - (18%)
Similarity:	238/665 - (35%)	Gaps:	184/665 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 GATSSDKEYLYET------KNKEALYADPLDDPYQRPV--------LWDDITTSIQNI------- 242
            |..||||:.:..|      .||.:.|:......::|.:        |..:.|.||.::
Yeast    84 GDGSSDKKNIDRTWNLGDENNKVSHYSKKSMSSHKRGLSGTAIFGFLGHNKTLSISSLQQSILNM 148

  Fly   243 --DPENALMLSSSGS-----SNNNGSSNSSSNTGESATSQLPQVKMEAIDESLLETFSTPLLSPL 300
              ||:...:::..|:     :||:...:...|.||:  |.|.||.::..:|             |
Yeast   149 SKDPQPMELINELGNHNTVKNNNDDFDHIRENDGEN--SYLSQVLLKQQEE-------------L 198

  Fly   301 EIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHYQQHYQQQHLYQHHPSLALPGLPP 365
            .|..|||:...:...:|.:..|.||::..:...:        |:...|:.:.....|.:.||.|.
Yeast   199 RIALEKQKEVNEKLEKQLRDNQIQQEKLRKVLEE--------QEEVAQKLVSGATNSNSKPGSPV 255

  Fly   366 AVDVVELQLQQQHQQQQHLQHNNSSSS---------SPKLATPGDNSGNTSSY-QQQYASQLVSG 420
            .:....:|..:.......:..|:::..         ||:::....|...:..| :|:|.::....
Yeast   256 ILKTPAMQNGRMKDNAIIVTTNSANGGYQFPPPTLISPRMSNTSINGSPSRKYHRQRYPNKSPES 320

  Fly   421 SG-------GGYLNGSSSNSYG------------YSWHSS------------------------- 441
            :|       .|||..|...|:.            |:.|::
Yeast   321 NGLNLFSSNSGYLRDSELLSFSPQNYNLNLDGLTYNDHNNTSDKNNNDKKNSTGDNIFRLFEKTS 385

  Fly   442 ------------QSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAP 494
                        .|..:.:.:....:.....|:.|.||..||....::::.....:..:......
Yeast   386 PGGLSISPRINGNSLRSPFLVGTDKSRDDRYAAGTFTPRTQLSPIHKKRESVVSTVSTISQLQDD 450

  Fly   495 STP----STSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTP--PPP 553
            :.|    :|.:.::.:::|.::|  ..:||:      |||..::.:..:.......:.||  .||
Yeast   451 TEPIHMRNTQNPTLRNANALASS--SVLPPI------PGSSNNTPIKNSLPQKHVFQHTPVKAPP 507

  Fly   554 YQQGHVMGLINPPPTL--QLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPT 616
            ....::..|:|.|...  ||.......:|:.|                    :.:..| |.||.|
Yeast   508 KNGSNLAPLLNAPDLTDHQLEIKTPIRNNSHC--------------------EVESYP-QVPPVT 551

  Fly   617 PRSSGGGRRGRHSHHQPGTAAHIASL---MSVRTVRYNRRNNP-------------ELEKRRIHH 665
                       |..|:..|....:.|   :..||........|             ||.. ::..
Yeast   552 -----------HDIHKSPTLHSTSPLPDEIIPRTTPMKITKKPTTLPPGTIDQYVKELPD-KLFE 604

  Fly   666 CDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCE 730
            |.:..|:||:.:..::::|.:.|..::||:|.:|.|...|.|:.:|.||...| .||.:.| .|.
Yeast   605 CLYPNCNKVFKRRYNIRSHIQTHLQDRPYSCDFPGCTKAFVRNHDLIRHKISH-NAKKYIC-PCG 667

  Fly   731 RSFARSDHLALHMKR 745
            :.|.|.|.|.:|..|
Yeast   668 KRFNREDALMVHRSR 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	25/98 (26%)
		C2H2 Zn finger	671..688	CDD:275368	4/16 (25%)
		zf-H2C2_2	680..707	CDD:290200	8/26 (31%)
		C2H2 Zn finger	696..718	CDD:275368	8/21 (38%)
		zf-H2C2_2	710..735	CDD:290200	9/24 (38%)
		C2H2 Zn finger	726..746	CDD:275368	8/20 (40%)
ACE2	NP_013232.1	COG5048	176..683	CDD:227381	107/573 (19%)
		C2H2 Zn finger	605..627	CDD:275368	5/21 (24%)
		C2H2 Zn finger	635..657	CDD:275368	8/21 (38%)
		C2H2 Zn finger	664..680	CDD:275368	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030