DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and Klf17

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_083692.2	Gene:	Klf17 / 75753	MGIID:	2181068	Length:	341	Species:	Mus musculus

Alignment Length:	360	Identity:	104/360 - (28%)
Similarity:	139/360 - (38%)	Gaps:	86/360 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   429 SSSNSYGYSWHSSQSFH----TKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQL- 488
            ||.||         .||    |:|.   |....|..|||..       .:..:::.:.|.::.|
Mouse    29 SSGNS---------GFHQPPATQYL---PEMMRSYMASAEE-------LRCNEREWESQLIRSLP 74

  Fly   489 -----CPPAAPSTPSTSSSSIS----------SSSASSASRHMFVPPLTPPSSDPGSPGSSMVAA 538
                 ||......|..:....|          .||.:......|...|.|....|.|.|.|::|.
Mouse    75 EHGVRCPSQLAPIPFQNYCQRSIGRGSHVMPVGSSGTLGVTISFSENLMPQGGLPSSRGVSVMAH 139

  Fly   539 AAAAAAQRRTTPPPPYQQGHVM-GLINPPPTLQLLGGAATGSN-------------NSCTTTL-- 587
            ::|.|......|..|...|.:. |::..|      |.|:.|::             |.|...:
Mouse   140 SSAPAMPYPMPPTVPATTGSLKHGILLVP------GMASAGTHAVAPFMDQMLHSINPCNPEMLP 198

  Fly   588 ---TTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVR 649
               ..|.|..:......:...|:.|..:.||||...|.        ..|.|:...
Mouse   199 ARFQQLLPLDSQDSLVTESNTQEEPFVREPPTPAPEGA--------ESPSTSRGA---------- 245

  Fly   650 YNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRH 714
             .||.:|   ..|.:.|.:..|.|.|||.|||.:|||.|||.||:.|.|..|.|:|.|||||.||
Mouse   246 -TRRQSP---VSRPYVCTYNSCGKSYTKRSHLVSHQRKHTGVKPFACDWNGCTWKFFRSDELGRH 306

  Fly   715 YRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPK 749
            .|.||..:|.||..|:|.|.|||||..|.:.||||
Mouse   307 KRIHTRYRPHKCDECDREFMRSDHLRQHKRTHLPK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	36/82 (44%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
Klf17	NP_083692.2	COG5048	<22..317	CDD:227381	89/334 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..252		12/59 (20%)
		zf-C2H2	256..280	CDD:278523	12/23 (52%)
		C2H2 Zn finger	261..280	CDD:275368	11/18 (61%)
		C2H2 Zn finger	288..310	CDD:275368	13/21 (62%)
		zf-H2C2_2	302..325	CDD:290200	12/22 (55%)
		zf-C2H2	316..338	CDD:278523	11/21 (52%)
		C2H2 Zn finger	318..338	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841531
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940