DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and klf17

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001039233.1	Gene:	klf17 / 734094	XenbaseID:	XB-GENE-939941	Length:	413	Species:	Xenopus tropicalis

Alignment Length:	453	Identity:	132/453 - (29%)
Similarity:	180/453 - (39%)	Gaps:	124/453 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 LALPGLPPAVD----VVELQLQQQHQQQQH-------LQHNNSSSSSPKLATPGDNSGN------ 405
            :|:..|.|..|    ::|..::::......       |.|.:|:.:.   .||..:.|.
Frog    22 MAMDDLRPLADMSYTIIEHCIKKEEDDLGKFVDLDFILAHTSSNQNG---GTPVGHGGTYPLPET 83

  Fly   406 ----TSSYQQQYASQLVSGSGGGYLNGSSSNSY--------------------GYSWHSSQSFHT 446
                :::|....:.......|||...||..:||                    ..|.||.:  :|
Frog    84 PESCSTTYDSDGSYTANHKYGGGSFAGSPHHSYVAELLTPDVPCIDVNPDFGLKASMHSRK--YT 146

  Fly   447 KYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASS 511
            :.::           |...|| ..|.|         ..||.|........|..|....|||
Frog   147 ELRV-----------SGMDTP-GHLPA---------DHLQHLSHKIKKERPEQSCMLGSSS---- 186

  Fly   512 ASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHVMGLINPP-PTLQLLGGA 575
                       |.|.|..||  .|...|:......:..|.|.|.|..|    :|| ||.::
Frog   187 -----------PTSPDCISP--IMEQKASIMQMHGQLLPNPAYSQHRV----SPPVPTEEM---- 230

  Fly   576 ATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPT-----PRSSGGGRRGRHSHH---Q 632
               |.|.|     .:.|  .:......|..|..|...|.||     |.:...|:.|.:...   .
Frog   231 ---SPNDC-----HMIP--ELHCLPLMPMAQHYPIATPYPTHFASQPPAQFHGQFGVYRDPMKVH 285

  Fly   633 PGTAAHIASLMSVRTVRY-----------NRRNNPELEKRR--IHHCDFVGCSKVYTKSSHLKAH 684
            |.....|.:..|...:.|           .:|......::|  .|:|::.||.|.||||||||||
Frog   286 PAMHGMIVTPPSSPLLEYYPAMSATDDCKPKRGRRSWARKRTATHNCEYPGCGKTYTKSSHLKAH 350

  Fly   685 QRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            .|.|||||||.|.|..|.|:||||||||||:|||||.:||:|.:|||:|:||||||||||||:
Frog   351 MRTHTGEKPYHCNWEGCGWKFARSDELTRHFRKHTGHRPFQCHLCERAFSRSDHLALHMKRHM 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	46/95 (48%)
		C2H2 Zn finger	671..688	CDD:275368	13/16 (81%)
		zf-H2C2_2	680..707	CDD:290200	18/26 (69%)
		C2H2 Zn finger	696..718	CDD:275368	15/21 (71%)
		zf-H2C2_2	710..735	CDD:290200	17/24 (71%)
		C2H2 Zn finger	726..746	CDD:275368	15/19 (79%)
klf17	NP_001039233.1	C2H2 Zn finger	335..354	CDD:275368	14/18 (78%)
		COG5048	<337..>397	CDD:227381	43/59 (73%)
		C2H2 Zn finger	362..384	CDD:275368	15/21 (71%)
		zf-H2C2_2	376..401	CDD:372612	17/24 (71%)
		C2H2 Zn finger	392..412	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100