DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and KLF10

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_005646.1	Gene:	KLF10 / 7071	HGNCID:	11810	Length:	480	Species:	Homo sapiens

Alignment Length:	349	Identity:	108/349 - (30%)
Similarity:	143/349 - (40%)	Gaps:	70/349 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 PSAAA------SATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSI---SSSS 508
            |..||      .:..||...|.||..:..:.....|....|.||..|.|..:..::|.   :..:
Human   128 PHIAAPFKEEEKSPVSAPKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNYQNNSFRRRTHLN 192

  Fly   509 ASSASRHMFVPPLTPPSS-------------------DPGSPGSSMV---AAAAAAAAQRRT--T 549
            ..:|.:::....::|..|                   |...|.|..|   :..|..:.|:::  .
Human   193 VEAARKNIPCAAVSPNRSKCERNTVADVDEKASAALYDFSVPSSETVICRSQPAPVSPQQKSVLV 257

  Fly   550 PPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPAS--------AIQQQQQQPQ-- 604
            .||....|.|      ||...:.......:||...||:...||.|        .:....|.|:
Human   258 SPPAVSAGGV------PPMPVICQMVPLPANNPVVTTVVPSTPPSQPPAVCPPVVFMGTQVPKGA 316

  Fly   605 -----QQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRI- 663
                 .|.|.|...||.  .|..|.|.......||.:...|.:            .|:::..||
Human   317 VMFVVPQPVVQSSKPPV--VSPNGTRLSPIAPAPGFSPSAAKV------------TPQIDSSRIR 367

  Fly   664 -HHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCI 727
             |.|...||.|.|.||||||||.|.||||||::|.|..||.||||||||:||.|.|||.|.|.|.
Human   368 SHICSHPGCGKTYFKSSHLKAHTRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHTGEKKFACP 432

  Fly   728 VCERSFARSDHLALHMKRHLPKNK 751
            :|:|.|.|||||..|.:|||...|
Human   433 MCDRRFMRSDHLTKHARRHLSAKK 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	43/84 (51%)
		C2H2 Zn finger	671..688	CDD:275368	12/16 (75%)
		zf-H2C2_2	680..707	CDD:290200	18/26 (69%)
		C2H2 Zn finger	696..718	CDD:275368	15/21 (71%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
KLF10	NP_005646.1	zf-C2H2	369..393	CDD:278523	15/23 (65%)
		COG5048	374..>424	CDD:227381	34/49 (69%)
		C2H2 Zn finger	374..393	CDD:275368	13/18 (72%)
		zf-H2C2_2	385..412	CDD:290200	18/26 (69%)
		C2H2 Zn finger	401..423	CDD:275368	15/21 (71%)
		zf-H2C2_2	415..438	CDD:290200	13/22 (59%)
		zf-C2H2	429..451	CDD:278523	11/21 (52%)
		C2H2 Zn finger	431..451	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040