DRSC/TRiP Functional Genomics Resources

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Protein Alignment dar1 and KLF5

DIOPT Version :9

Sequence 1:NP_001097493.1 Gene:dar1 / 38436 FlyBaseID:FBgn0263239 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_001721.2 Gene:KLF5 / 688 HGNCID:6349 Length:457 Species:Homo sapiens


Alignment Length:409 Identity:148/409 - (36%)
Similarity:188/409 - (45%) Gaps:115/409 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   445 HTKYQIHPPSAAASATASATAT----PTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSIS 505
            |.:.|..|..|.|...|...||    |...|   .|.:.:.::.|....|| .|..|........
Human    55 HHRPQAQPAPAQAPQPAQPPATGPRLPPEDL---VQTRCEMEKYLTPQLPP-VPIIPEHKKYRRD 115

  Fly   506 SSSA------------SSASRHMFVPPLT----------------------------------PP 524
            |:|.            .|.:.::|:|.:|                                  ||
Human   116 SASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPP 180

  Fly   525 SSDPGSPGSSMVAAAAAAAAQ-------RRTTPPP------PYQQGHVMGLINPP---------- 566
            :.....|..:.:.::...||.       ::..|.|      |.||||:..|:|.|          
Human   181 APTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQ 245

  Fly   567 ----PTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQP------QQQQVPQQQP--PPTPRS 619
                .||.:...||....|    |.|:..|.:|::|.|..|      ..|.:|||..  ||:|.|
Human   246 TAAMDTLNVSMSAAMAGLN----THTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPS 306

  Fly   620 SGGGRRGRHSH------HQPGTAAHIASLM----------------SVRTVRYNRRNNPELEKRR 662
            |..|...|.:.      ..|..||.|||.:                :::.||||||:||:|||||
Human   307 SEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRR 371

  Fly   663 IHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCI 727
            ||:||:.||:||||||||||||.|.|||||||.|.|..|:||||||||||||||||||||||:|.
Human   372 IHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCG 436

  Fly   728 VCERSFARSDHLALHMKRH 746
            ||.|||:||||||||||||
Human   437 VCNRSFSRSDHLALHMKRH 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dar1NP_001097493.1 COG5048 641..>724 CDD:227381 63/98 (64%)
C2H2 Zn finger 671..688 CDD:275368 14/16 (88%)
zf-H2C2_2 680..707 CDD:290200 19/26 (73%)
C2H2 Zn finger 696..718 CDD:275368 17/21 (81%)
zf-H2C2_2 710..735 CDD:290200 21/24 (88%)
C2H2 Zn finger 726..746 CDD:275368 16/19 (84%)
KLF5NP_001721.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83 9/27 (33%)
9aaTAD. /evidence=ECO:0000269|PubMed:31375868 118..126 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..321 9/25 (36%)
Interaction with WWP1. /evidence=ECO:0000269|PubMed:15735697 324..328 1/3 (33%)
COG5048 359..>433 CDD:227381 60/73 (82%)
C2H2 Zn finger 378..397 CDD:275368 15/18 (83%)
C2H2 Zn finger 405..427 CDD:275368 17/21 (81%)
zf-C2H2 433..455 CDD:306579 17/21 (81%)
C2H2 Zn finger 435..455 CDD:275368 16/19 (84%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I12146
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006531
OrthoInspector 1 1.000 - - oto91683
orthoMCL 1 0.900 - - OOG6_107236
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3166
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.870

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