DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and SP3

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_003102.1	Gene:	SP3 / 6670	HGNCID:	11208	Length:	781	Species:	Homo sapiens

Alignment Length:	762	Identity:	182/762 - (23%)
Similarity:	270/762 - (35%)	Gaps:	208/762 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 HHQHHHLHQHHSHSLQSGESGASEAWP-----------HLPAPSYASDVPHAQQQQLQPAGSP-N 165
            |.::....|.|.:...:..:.|.:..|           .:..||...|    :::....||:| .
Human    30 HGEYLQQQQQHGNGAVAAAAAAQDTQPSPLALLAATCSKIGPPSPGDD----EEEAAAAAGAPAA 90

  Fly   166 SNSNGAYGCAPLYDGAP--YEVALG-------YGGAVVASTGGATSSDKEY---LYETKNKEALY 218
            :.:.|....|.| .|||  :||...       ..|.:|.....||||. :|   |...:|::...
Human    91 AGATGDLASAQL-GGAPNRWEVLSATPTTIKDEAGNLVQIPSAATSSG-QYVLPLQNLQNQQIFS 153

  Fly   219 ADPLDD---------PYQRPVLWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGESATS 274
            ..|..|         .||       :...||:.|.:. :.:..:|||:|.|.:..||
Human   154 VAPGSDSSNGTVSSVQYQ-------VIPQIQSADGQQ-VQIGFTGSSDNGGINQESS-------- 202

  Fly   275 QLPQVKMEAIDESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQ 339
               |:::.......|....||            ....|:...|..|.|.|...........|.|
Human   203 ---QIQIIPGSNQTLLASGTP------------SANIQNLIPQTGQVQVQGVAIGGSSFPGQTQ- 251

  Fly   340 QHYQQHYQQQHLYQHHPSLALPG----LP-PAVDVVELQLQQQHQQQ--------------QHLQ 385
                       :..:.| |.|||    :| .:||:..|.|....|..              |.:.
Human   252 -----------VVANVP-LGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTGQAMD 304

  Fly   386 HNNSSSSSPKLATPGDNSGNT---------SSYQ-----------QQYASQLVSGSGGGYLNGSS 430
            .:::|..:.:..:|..|..||         ||.|           ||..:.|.:.||..:    |
Human   305 SSDNSERTGERVSPDINETNTDTDLFVPTSSSSQLPVTIDSTGILQQNTNSLTTSSGQVH----S 365

  Fly   431 SNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQ-LGAQQQQQQQQQQQLQQLCPPAAP 494
            |:..|....|..|..|:         |.....:||.|..| |..|:.||...|.|:.|...|...
Human   366 SDLQGNYIQSPVSEETQ---------AQNIQVSTAQPVVQHLQLQESQQPTSQAQIVQGITPQTI 421

  Fly   495 STPSTSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHV 559
            .....|..:||..:..:....:             :||:.::.|.....:.:.|     :|...|
Human   422 HGVQASGQNISQQALQNLQLQL-------------NPGTFLIQAQTVTPSGQVT-----WQTFQV 468

  Fly   560 MGLIN-----------------PPPTLQL----LGGAATGSNNSCTT----TLTTLT----PASA 595
            .|:.|                 |..||.|    .|||.|.:..|.:|    .|.|:|    .::.
Human   469 QGVQNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGAFTSTPVSLSTGQLPNLQTVTVNSIDSAG 533

  Fly   596 IQ----QQQQQPQQQQVPQQQPPPTPRSSGG-----------------GRRGRHSHHQPGTAAHI 639
            ||    :....|...::.:::|.|......|                 ...|...|.:......:
Human   534 IQLHPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRV 598

  Fly   640 ASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWR 704
            |  .:....:........|.|::.|.|...||.|||.|:|||:||.|.|:||:|:.|.|..|..|
Human   599 A--CTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFVCNWMYCGKR 661

  Fly   705 FARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK 751
            |.|||||.||.|.|||.|.|.|..|.:.|.||||||.|:|.|  :||
Human   662 FTRSDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH--QNK 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	37/82 (45%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	14/26 (54%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	11/19 (58%)
SP3	NP_003102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	65..88		5/26 (19%)
		Transactivation domain (Gln-rich)	138..237		25/129 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338		8/36 (22%)
		Transactivation domain (Gln-rich)	350..499		39/179 (22%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	461..469		2/12 (17%)
		Repressor domain	534..620		11/87 (13%)
		C2H2 Zn finger	623..645	CDD:275368	13/21 (62%)
		COG5048	<636..718	CDD:227381	42/73 (58%)
		zf-H2C2_2	637..664	CDD:290200	14/26 (54%)
		C2H2 Zn finger	653..675	CDD:275368	13/21 (62%)
		zf-H2C2_2	667..690	CDD:290200	12/22 (55%)
		zf-C2H2	681..703	CDD:278523	12/21 (57%)
		C2H2 Zn finger	683..703	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940