DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and SP1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_612482.2	Gene:	SP1 / 6667	HGNCID:	11205	Length:	785	Species:	Homo sapiens

Alignment Length:	837	Identity:	197/837 - (23%)
Similarity:	276/837 - (32%)	Gaps:	275/837 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SNNNHS----------------SNSSSNNSNG--SQTPNGNNNSSLATGGHQHHQFHHHLHHHHS 109
            |:.:||                :|..:.|..|  ||..:.:..||.:|||
Human     2 SDQDHSMDEMTAVVKIEKGVGGNNGGNGNGGGAFSQARSSSTGSSSSTGG--------------- 51

  Fly   110 HQHHHQHHHLHQHHSHSLQSGESGASEAWPHLPAPSYASDVPHAQQQQLQPAGSPNSNSNGAYGC 174
                                   |..|:.|. |....|:.....:        |||.|||.:.|
Human    52 -----------------------GGQESQPS-PLALLAATCSRIE--------SPNENSNNSQG- 83

  Fly   175 APLYDGAPYEVAL--------GYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVL 231
             |...|...|:.|        ..|..:::|:.|||.:.||
Human    84 -PSQSGGTGELDLTATQLSQGANGWQIISSSSGATPTSKE------------------------- 122

  Fly   232 WDDITTSIQNIDPENALMLSSSGSSNN--NGSSNSSSNT---GESATSQLPQVK----------- 280
                                .||||.|  |||.:|.:.|   |:...:..|.::
Human   123 --------------------QSGSSTNGSNGSESSKNRTVSGGQYVVAAAPNLQNQQVLTGLPGV 167

  Fly   281 MEAIDESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQH---- 341
            |..|...::..|.|         .:.||.|......|.||....|.|.....:||....:.
Human   168 MPNIQYQVIPQFQT---------VDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIITNRGSGGN 223

  Fly   342 --------YQQHYQQQHL----------YQHHPSLALPG----LPPAVDVVELQLQQQHQQQQHL 384
                    .||....|.|          |..:..:||.|    ||  |:.|.........|...:
Human   224 IIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLP--VNSVSAATLTPSSQAVTI 286

  Fly   385 QHNNSSSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGGYLNGSSSNSYG-YSWHSSQSFHTKY 448
            ..:.|..|..:..|.|....:.|....|.:|.....:...|...:::::.| .::.:|.|..|..
Human   287 SSSGSQESGSQPVTSGTTISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTTSGSSGTNS 351

  Fly   449 QIHPP--------SAAASATASATATPTAQLGAQQQQQQQQQQQLQQ-LCPP------------- 491
            |...|        |.|.:...:.|:..:.|.|.|::.:|.||.|.|| |..|
Human   352 QGQTPQRVSGLQGSDALNIQQNQTSGGSLQAGQQKEGEQNQQTQQQQILIQPQLVQGGQALQALQ 416

  Fly   492 AAPSTPSTSSSSISSSSASSASRHMFVPPLTP-----PSSDPGSPGSSMVAAAAAAAAQRRTTPP 551
            |||.:..|.::...|.......:...||...|     |:..|....|...........|
Human   417 AAPLSGQTFTTQAISQETLQNLQLQAVPNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQ------ 475

  Fly   552 PPYQQGHVMGLINPPP---TLQLLGGAATGSNNSCTTTLTTLTPASAI---------QQQQQQPQ 604
                        ||..   ||..:.|.:.|..:|..||||.:..|::|         .|....|.
Human   476 ------------NPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLSSMPG 528

  Fly   605 QQQV-------------PQQQPP----PTPRSSG------------------GGRRGRHS-HHQP 633
            .|.:             |.|..|    ..|...|                  ||..|.:| ..||
Human   529 LQTINLSALGTSGIQVHPIQGLPLAIANAPGDHGAQLGLHGAGGDGIHDDTAGGEEGENSPDAQP 593

  Fly   634 GTAAHIASLMSVRTVRYNR----RNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPY 694
              .|...:.....|..|.:    |.:.:..|::.|.|...||.|||.|:|||:||.|.||||:|:
Human   594 --QAGRRTRREACTCPYCKDSEGRGSGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERPF 656

  Fly   695 TCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK 751
            .|.|..|..||.|||||.||.|.|||.|.|.|..|.:.|.|||||:.|:|.|  :||
Human   657 MCTWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH--QNK 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	40/86 (47%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
SP1	NP_612482.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93		27/139 (19%)
		Repressor domain	2..82		24/126 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..141		15/76 (20%)
		Transactivation domain A (Gln-rich)	146..251		19/113 (17%)
		Transactivation domain B (Gln-rich)	261..495		52/253 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..395		15/65 (23%)
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	462..470		1/7 (14%)
		Transactivation domain C (highly charged)	496..610		24/115 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..598		7/32 (22%)
		VZV IE62-binding	619..785		51/95 (54%)
		C2H2 Zn finger	628..650	CDD:275368	13/21 (62%)
		zf-H2C2_2	642..669	CDD:290200	15/26 (58%)
		C2H2 Zn finger	658..680	CDD:275368	13/21 (62%)
		zf-H2C2_2	672..695	CDD:290200	12/22 (55%)
		zf-C2H2	686..708	CDD:278523	11/21 (52%)
		C2H2 Zn finger	688..708	CDD:275368	10/19 (53%)
		Domain D	708..785		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940