DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and klf4

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001106955.1	Gene:	klf4 / 562155	ZFINID:	ZDB-GENE-111014-1	Length:	396	Species:	Danio rerio

Alignment Length:	424	Identity:	131/424 - (30%)
Similarity:	174/424 - (41%)	Gaps:	134/424 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 LPPAVDVVELQ---------------LQQQHQQQQHLQHNNSSSSSPKLATPGDNSGNTSSYQQQ 412
            :||.:..:|.:               ||||.|||.      |:|.:...::|...:....|.|.|
Zfish    68 VPPVMAKIEPEELELLDYDFILSNSLLQQQQQQQA------STSRTIPASSPTHYTFPMPSPQGQ 126

  Fly   413 YASQL--------VSGSGG------------GYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAA 457
            ..|.|        ||.|||            .||..:       |.|......|...:...:...
Zfish   127 EGSMLYTIPDISDVSPSGGFVAELMRPELDPAYLQPT-------SLHGKFVVKTTMDMSDYNQGV 184

  Fly   458 SATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLT 522
            |.:..|:|.|.|                   ||......|||          .:|||.|.: .|.
Zfish   185 SISKDASAVPFA-------------------CPRIKQECPST----------CTASRPMDL-HLR 219

  Fly   523 PPSSDPGSPGSSMV--AAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTT 585
            ..|:..|....||:  .|.::....|.:..|..:.|...:|....|.|      |.:|...:
Zfish   220 GSSAQSGVHQGSMLDPHAFSSGRGARSSLSPDEHPQAPGLGSGYHPNT------AYSGFPQA--- 275

  Fly   586 TLTTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRY 650
                  ||.::|.|:.....:.:|::..|         :|||.|
Zfish   276 ------PAQSLQYQELISPAEGLPEESKP---------KRGRRS--------------------- 304

  Fly   651 NRRNNPELEKRRI--HHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTR 713
                   ..::||  |.||:.||.|.||||||||||.|.|||||||.|.|..|.|:|||||||||
Zfish   305 -------WPRKRIATHTCDYAGCGKTYTKSSHLKAHHRTHTGEKPYHCDWEGCGWKFARSDELTR 362

  Fly   714 HYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            |||||||.:||:|:.|:|:|:|||||||||||||
Zfish   363 HYRKHTGIRPFQCLKCDRAFSRSDHLALHMKRHL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	46/84 (55%)
		C2H2 Zn finger	671..688	CDD:275368	13/16 (81%)
		zf-H2C2_2	680..707	CDD:290200	18/26 (69%)
		C2H2 Zn finger	696..718	CDD:275368	16/21 (76%)
		zf-H2C2_2	710..735	CDD:290200	17/24 (71%)
		C2H2 Zn finger	726..746	CDD:275368	14/19 (74%)
klf4	NP_001106955.1	zf-C2H2	313..337	CDD:278523	17/23 (74%)
		C2H2 Zn finger	315..337	CDD:275368	16/21 (76%)
		COG5048	<320..>375	CDD:227381	42/54 (78%)
		C2H2 Zn finger	345..367	CDD:275368	16/21 (76%)
		zf-H2C2_2	359..384	CDD:290200	17/24 (71%)
		C2H2 Zn finger	375..395	CDD:275368	14/19 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100