DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and sp3a

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_005167474.1	Gene:	sp3a / 558652	ZFINID:	ZDB-GENE-070410-111	Length:	691	Species:	Danio rerio

Alignment Length:	699	Identity:	166/699 - (23%)
Similarity:	239/699 - (34%)	Gaps:	198/699 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 AGSPNSNSNGAYGCAPLYDGAPYEVAL------GYGGAVVASTGGATSSDKEYLYETKNKEALYA 219
            ||....:|:...|.....||.|..:||      |.|.....:..||:|::     .:....|..:
Zfish    10 AGVMADSSSAQDGGGAEQDGQPSPLALLAATCTGLGSPAPGAENGASSNN-----ASAGVNADLS 69

  Fly   220 DPLDDPYQRPVLWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGESATSQLPQVKMEAI 284
            |.|....:|   |:.:.      |....|.|..:|...:||.            ..||...::.:
Zfish    70 DQLTSSTER---WEAVR------DDSGVLHLPGTGIVTSNGQ------------YVLPLQSLQGL 113

  Fly   285 DESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHYQQHYQQQ 349
            ..           .|:.:.:..........:.|.|...|.|....|.........|....|.|
Zfish   114 QN-----------QPILLTSGTDASAGAVPNIQYQVIPQVQTTDGQLGFSGASMAQDATGHIQ-- 165

  Fly   350 HLYQHHPSLALPGLPPAVDVVELQ--------LQQQHQQQQHLQHNNSSS------SSPKLATPG 400
                     .||.....:.|....        :.|..|..|..|.:..||      ::..|..||
Zfish   166 ---------ILPDGTQTISVTSADVLSNSQSLMTQTGQVHQIPQVSLGSSAFGGQVTNVPLGLPG 221

  Fly   401 D------NSGNTSSYQQQYASQLVSG-SGGGYL---NGSSSNSYGYSWHSSQSFHTKY---QIHP 452
            :      ||.:..|.....|..:.:| :..|.|   |.|..||........|:..|..   ...|
Zfish   222 NITFVPINSVDLDSLGLSGAQPIATGITADGQLIMTNQSVENSEKAGEQQQQTLSTNATADMFVP 286

  Fly   453 PSAAASATASATATPTAQL------------------GAQQQQQQQQQQQLQQLCPPAAPSTPST 499
            .:::.|::.:.|...|..|                  ||.|....||..|||||        |..
Zfish   287 TTSSVSSSQATTIDGTGVLTQQPVAGEQTDSSGYLSQGAVQVSGGQQVIQLQQL--------PLQ 343

  Fly   500 SSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPP---PYQQGHVMG 561
            |:...:|:.|....:::.:.          :||:.::        |.:|..|.   .:|...|.|
Zfish   344 SADGQASAQAQQTMQNIQLI----------NPGTFLI--------QAQTVTPSGQIQWQTFQVQG 390

  Fly   562 LIN-----------------PPPTLQL-LGGAATGSN-----NSCTTTLTTLTPASAIQQQQQQP 603
            :.|                 |..||.| .||.....:     |..:.|:.|:..| .||.||.:.
Zfish   391 VQNLQNLQLQTAPTQQITLAPVQTLSLGQGGTPVSLSSGQMPNLQSVTVNTVGQA-GIQFQQSED 454

  Fly   604 -------QQQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYN---------- 651
                   |.::.|..:..|...||             ...|:..|.:.||.|...
Zfish   455 TDSTGDIQIKEEPDSEEWPLDSSS-------------TLNANDLSHLRVRLVEEEMEALSQEGKR 506

  Fly   652 -RR-------------NNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECE 702
             ||             ....:.|::.|.|...||.|||.|:|||:||.|.|:||:|:.|.|..|.
Zfish   507 LRRVACTCPNCKEGGGRGSNMGKKKQHVCHIAGCGKVYGKTSHLRAHLRWHSGERPFVCTWMFCG 571

  Fly   703 WRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK 751
            .||.|||||.||.|.|||.|.|.|..|.:.|.||||||.|:|.|  :||
Zfish   572 KRFTRSDELQRHRRTHTGEKKFVCSECSKRFMRSDHLAKHIKTH--QNK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	42/106 (40%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	14/26 (54%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	11/19 (58%)
sp3a	XP_005167474.1	Fimbrial	125..230	CDD:294848	20/115 (17%)
		zf-C2H2	533..557	CDD:278523	14/23 (61%)
		C2H2 Zn finger	535..557	CDD:275368	13/21 (62%)
		COG5048	<548..619	CDD:227381	42/73 (58%)
		zf-H2C2_2	549..576	CDD:290200	14/26 (54%)
		C2H2 Zn finger	565..587	CDD:275368	13/21 (62%)
		zf-H2C2_2	579..602	CDD:290200	12/22 (55%)
		zf-C2H2	593..615	CDD:278523	12/21 (57%)
		C2H2 Zn finger	595..615	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940