DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and KLF13

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_057079.2	Gene:	KLF13 / 51621	HGNCID:	13672	Length:	288	Species:	Homo sapiens

Alignment Length:	318	Identity:	93/318 - (29%)
Similarity:	127/318 - (39%)	Gaps:	99/318 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 SFHTKYQIHPPSAAASAT---ASATATPTAQLGAQQQQQQQQQQ---------QLQQLCPPAAPS 495
            |..::..:|.|.....:.   |:..||||.....:::..:....         .|.|..|..||
Human    17 SMSSRAVVHGPREGPESRPEGAAVAATPTLPRVEERRDGKDSASLFVVARILADLNQQAPAPAP- 80

  Fly   496 TPSTSSSSISSSSASSASRHMFVP-PLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHV 559
                     :.....:|:|....| .|.||:.:|.|||:...|||          ||.|
Human    81 ---------AERREGAAARKARTPCRLPPPAPEPTSPGAEGAAAA----------PPSP------ 120

  Fly   560 MGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSSGGGR 624
                                                 ...:.:|:....|:::|.|    :|.|.
Human   121 -------------------------------------AWSEPEPEAGLEPEREPGP----AGSGE 144

  Fly   625 RGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEK-RRIHHCDFVGCSKVYTKSSHLKAHQRIH 688
            .|.....:.|                  |:..:||. :|.|.|.:.||.|||.||||||||.|.|
Human   145 PGLRQRVRRG------------------RSRADLESPQRKHKCHYAGCEKVYGKSSHLKAHLRTH 191

  Fly   689 TGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRH 746
            |||:|:.|.|.:|..:|||||||.||||.|||.|.|.|.:||:.|.|||||..|.:||
Human   192 TGERPFACSWQDCNKKFARSDELARHYRTHTGEKKFSCPICEKRFMRSDHLTKHARRH 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	43/83 (52%)
		C2H2 Zn finger	671..688	CDD:275368	13/16 (81%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	14/21 (67%)
		zf-H2C2_2	710..735	CDD:290200	15/24 (63%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
KLF13	NP_057079.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..57		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..166		32/179 (18%)
		COG5048	<162..252	CDD:227381	53/88 (60%)
		zf-C2H2	167..191	CDD:278523	16/23 (70%)
		C2H2 Zn finger	169..191	CDD:275368	15/21 (71%)
		zf-H2C2_2	183..210	CDD:290200	15/26 (58%)
		C2H2 Zn finger	199..221	CDD:275368	14/21 (67%)
		zf-H2C2_2	213..236	CDD:290200	14/22 (64%)
		zf-C2H2	227..249	CDD:278523	11/21 (52%)
		C2H2 Zn finger	229..249	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..288		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910