DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dar1 and KLF3

DIOPT Version :9

Sequence 1:NP_001097493.1 Gene:dar1 / 38436 FlyBaseID:FBgn0263239 Length:751 Species:Drosophila melanogaster
Sequence 2:NP_057615.3 Gene:KLF3 / 51274 HGNCID:16516 Length:345 Species:Homo sapiens


Alignment Length:385 Identity:125/385 - (32%)
Similarity:171/385 - (44%) Gaps:99/385 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   411 QQYASQLVSGS-GGGYLNGSSSNSYG--YS-------WHSSQSFHTKYQIHPPSAAASATASATA 465
            :|.|...||.| ...|:.....|.||  ||       :.:.:......|:.|.....:..:|   
Human    10 KQEAMDPVSVSYPSNYMESMKPNKYGVIYSTPLPEKFFQTPEGLSHGIQMEPVDLTVNKRSS--- 71

  Fly   466 TPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPP--SSDP 528
                                    ||:|.::|   ||....||...||..:.:|..:||  ...|
Human    72 ------------------------PPSAGNSP---SSLKFPSSHRRASPGLSMPSSSPPIKKYSP 109

  Fly   529 GSPG-------SSMVAAAAAAAAQRRTTPP---PPYQQGHVMGLINPPPTL-------QLLGGAA 576
            .|||       .||....|||.::.....|   |..|.    .::.|.|.:       .|:...:
Human   110 PSPGVQPFGVPLSMPPVMAAALSRHGIRSPGILPVIQP----VVVQPVPFMYTSHLQQPLMVSLS 170

  Fly   577 TGSNNSCTTTLTTLTPA--SAIQQQQ------QQPQQ-QQVPQQQPPPTPRSSGGGRRGRHSHH- 631
            ....||.::....:..:  ..|.|::      .:||: ...|::..||...|....:.....:| 
Human   171 EEMENSSSSMQVPVIESYEKPISQKKIKIEPGIEPQRTDYYPEEMSPPLMNSVSPPQALLQENHP 235

  Fly   632 ----QPGTAAHIASLMSVRTVRYNRR----NNPELE-KRRIHHCDFVGCSKVYTKSSHLKAHQRI 687
                |||                 :|    .:|:.: |||||.||:.||:||||||||||||:|.
Human   236 SVIVQPG-----------------KRPLPVESPDTQRKRRIHRCDYDGCNKVYTKSSHLKAHRRT 283

  Fly   688 HTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            |||||||.|.|..|.|:||||||||||:|||||.|||:|..|:|||:||||||||.|||:
Human   284 HTGEKPYKCTWEGCTWKFARSDELTRHFRKHTGIKPFQCPDCDRSFSRSDHLALHRKRHM 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dar1NP_001097493.1 COG5048 641..>724 CDD:227381 51/87 (59%)
C2H2 Zn finger 671..688 CDD:275368 14/16 (88%)
zf-H2C2_2 680..707 CDD:290200 18/26 (69%)
C2H2 Zn finger 696..718 CDD:275368 15/21 (71%)
zf-H2C2_2 710..735 CDD:290200 18/24 (75%)
C2H2 Zn finger 726..746 CDD:275368 14/19 (74%)
KLF3NP_057615.3 Repressor domain 1..74 15/90 (17%)
KLF3_N 49..260 CDD:410554 50/261 (19%)
9aaTAD, inactive. /evidence=ECO:0000269|PubMed:31375868 60..68 1/7 (14%)
CTBP-binding motif 61..65 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 66..112 15/75 (20%)
zf-C2H2 260..284 CDD:395048 18/23 (78%)
C2H2 Zn finger 262..284 CDD:275368 17/21 (81%)
C2H2 Zn finger 292..314 CDD:275368 15/21 (71%)
zf-H2C2_2 306..331 CDD:404364 18/24 (75%)
C2H2 Zn finger 322..342 CDD:275368 14/19 (74%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23235
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.