DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and Spps

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001262902.1	Gene:	Spps / 42882	FlyBaseID:	FBgn0039169	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	787	Identity:	212/787 - (26%)
Similarity:	290/787 - (36%)	Gaps:	230/787 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KIEPADVELEVLAAAAAAANNNNNTSS-------------NNNHSSNSSSNNSNGSQTPNGNNNS 88
            ::....|:.:.....|:.||.:..|:|             ..|....:|...:|| ...|.:|.|
  Fly   189 QVHQGTVQQQAQGTNASGANGSGVTNSGTAGQLPGSITIPGTNLQIPTSVAAANG-LLGNISNIS 252

  Fly    89 SLATGGHQHHQFHHHLHHHHSHQHHHQHHHLHQHHSHSLQSGESGASEAWPHLPAPSYASDVPHA 153
            :|..||                            .|..|::|:..........|||:    :|
  Fly   253 NLLGGG----------------------------QSIKLENGQLQMRPQLVQFPAPA----MP-- 283

  Fly   154 QQQQLQPAGSPNSNSNGAYGCAPLYDGAPYEVALGYGGAVVASTGGATSSDKEYLYETKNKEALY 218
            ||||......|...:||    ..:|......|.     |...|:||.             :..:.
  Fly   284 QQQQTVAVQIPVQTANG----QTIYQTVHVPVQ-----AAATSSGGL-------------QNLMQ 326

  Fly   219 ADPLDDPYQRPVLWDDITTSIQNIDP---ENALMLSSSGSSNNNGSSNSSSNTGESATSQLPQVK 280
            |..|..|          :.|...|.|   :.|.:::.:|                    |:.||:
  Fly   327 AQSLQMP----------SASQMQIIPQFSQIAQIVTPNG--------------------QIQQVQ 361

  Fly   281 MEAIDESLLETFSTPLLSP----LEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQQYQQQH 341
            :         ....|.|.|    :.|:...||:|||.|.||||||.|||||..|||.|||.|||.
  Fly   362 L---------AMPYPQLPPNANIIHIQNPHQQQQQQVQQQQQQQQAQQQQQAQQQQAQQQQQQQV 417

  Fly   342 YQQHYQQQHLYQHHPSLALPG-LPP--AVDVVELQLQQQHQQQQHLQHNNSSSSSPKLATPGDNS 403
            ..||   |.|.|.....:..| |||  .:.:...|.||.......|:.|     :|...||.. :
  Fly   418 QAQH---QQLLQAISDASAGGQLPPNQPITITNAQGQQLTVIPAQLRPN-----APTAPTPAP-A 473

  Fly   404 GNTSSYQ----QQYASQLVSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASAT 464
            |..:..|    |....|.:.|.|                 ..|..|.. |: ||:..|:.....|
  Fly   474 GVPTPMQMPNLQALPIQNIPGLG-----------------QVQIIHAN-QL-PPNLPANFQQVLT 519

  Fly   465 ATPTAQLGAQQQQQ------QQQQQQLQQLC------------------PPAAPSTPSTS----- 500
            ..|.:....|.|.|      |:.|...|.:.                  |||..|||:|:
  Fly   520 QLPMSHPQVQTQGQVQVMPKQEPQSPTQMITSIKQEPPDTFGPISATGNPPAPASTPNTASPQQQ 584

  Fly   501 --------SSSISSSSASSASRHMFVP------PLTPPSSDP---GSPGSSMVAAAAAAAAQRRT 548
                    |:|:||.|..::.:...:|      |.||.::.|   ..|..|.|.|...::.|...
  Fly   585 QIKFLHTESNSLSSLSIPASIQITALPQQATNTPNTPATTQPIPVSLPARSKVNAVTTSSTQITI 649

  Fly   549 TPPPPYQQGHVMGLINPPPTLQLLGGAAT-GSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQ 612
            .|    ..|.|:.:     |.|..|..|: .|.|:.|||:||             |.|..:...
  Fly   650 AP----TGGQVVSV-----TTQARGATASIRSTNTSTTTITT-------------PSQSHLNMN- 691

  Fly   613 PPPTPRSSGGGRRGRHSHHQPGTAAHIAS--LMSVRTVRYNRRNNPE-LEKRRIHHCDFVGCSKV 674
              .:..|.||...|...    |||.....  |..|.....|..:..: .:|:|.|.|...||.||
  Fly   692 --ISVASVGGAATGGGG----GTATGEPKPRLKRVACTCPNCTDGEKHSDKKRQHICHITGCHKV 750

  Fly   675 YTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHL 739
            |.|:|||:||.|.||||:|:.|.|..|..||.|||||.||.|.|||.|.|:|..|.:.|.|||||
  Fly   751 YGKTSHLRAHLRWHTGERPFVCSWAFCGKRFTRSDELQRHRRTHTGEKRFQCQECNKKFMRSDHL 815

  Fly   740 ALHMKRH 746
            :.|:|.|
  Fly   816 SKHIKTH 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	41/85 (48%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
Spps	NP_001262902.1	COG5048	<725..827	CDD:227381	51/98 (52%)
		C2H2 Zn finger	742..764	CDD:275368	13/21 (62%)
		zf-H2C2_2	756..783	CDD:290200	15/26 (58%)
		C2H2 Zn finger	772..794	CDD:275368	13/21 (62%)
		zf-H2C2_2	786..809	CDD:290200	12/22 (55%)
		zf-C2H2	800..822	CDD:278523	11/21 (52%)
		C2H2 Zn finger	802..822	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040