DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and sr

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001262693.1	Gene:	sr / 42162	FlyBaseID:	FBgn0003499	Length:	1271	Species:	Drosophila melanogaster

Alignment Length:	869	Identity:	224/869 - (25%)
Similarity:	316/869 - (36%)	Gaps:	292/869 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 AAAAAAANNNNNTSSNNNHSSNSSSNNSNGSQTPNGNNNSSLATGGHQHHQFHHHLHHHHSHQHH 113
            |||||||:.||:.....|.::..:...|.|
  Fly   383 AAAAAAASANNSVLRARNQTATPTQGGSPG----------------------------------- 412

  Fly   114 HQHHHLHQHHSHSLQSGESGASE------AWPHLPAPSYASDV-PHAQQQQLQPA--GSPNSNSN 169
                |:....|.:..||.|.||.      :..|.|..|....| .|.|..:..|.  .:|.:.|:
  Fly   413 ----HVAVQPSATASSGRSSASHLSLLNTSGQHSPTSSAVEQVEAHKQLIEALPGDLNTPVTTSS 473

  Fly   170 GAYGCAPLYDGAPYEVALGYGGAVVAS----TGGATSSD---KEYLYETKNKEALYADPLDDPYQ 227
                          ::...:|...|..    ||...|.|   :..:....:....:..||.:...
  Fly   474 --------------DIPSFFGPTTVVEPPPITGSIESEDLSLEPQVISVASPVLSHCSPLKEERS 524

  Fly   228 RP----VLWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGESATSQLPQVKMEAIDESL 288
            .|    ::.::.:.:..|:.|::    :::.::|||.:|:|::.|.:..||           ||.
  Fly   525 TPPALAIVKEESSNNSCNMYPQH----NNNNNNNNNTTSSSTTTTSKQTTS-----------ESN 574

  Fly   289 LETFSTPLLSPLEIKTEKQQRQQQ---------------HQHQQQQQQQQQQQ----QQHQQQHQ 334
            .|...:|     ...|:..|:|||               |.|||||||||||.    ||..||||
  Fly   575 TECVGSP-----GNHTQSHQQQQQQLQHNNTSSSNSNCHHSHQQQQQQQQQQHMSSPQQQYQQHQ 634

  Fly   335 QQYQQQHYQQHYQQQHLYQHHPSLALPGLPPAVDVVELQLQQQHQQQQH---------------- 383
            ..:|||....|:...|.:.||.|        .:..::.|.|||.|||||
  Fly   635 ILHQQQQLPNHHHHHHHHHHHHS--------QLQQLQQQQQQQQQQQQHQQQPLHQQQQLQHQQQ 691

  Fly   384 ------------LQHNNSSSSSPKLATPG--DNSGNTSS---------------YQQQYASQLVS 419
                        :||..|...:.|::..|  ..:||..:               .|||:..||.|
  Fly   692 QQHHQQHYQQHAIQHQQSQQQASKISYRGIFTTTGNAMNAAAAAAAAAAQQQHQQQQQHQQQLPS 756

  Fly   420 GSGGGYLNGSS--SNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQ 482
            ...|......|  |||.|.||.......|.:|  ||..:..|..:     |.|...|||||||||
  Fly   757 PQLGVLAGPMSPPSNSLGNSWGLPSPDKTMFQ--PPLFSLPAHYA-----TMQQQQQQQQQQQQQ 814

  Fly   483 QQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLT-----------PPS---SDPGSPGS 533
            ||.||    ||.:.||....  ..::|::|::|..:..||           |||   :..|.||.
  Fly   815 QQQQQ----AAGAAPSPYDD--GRAAAAAAAQHAELLGLTMDCTPLLLKQPPPSYAGASAGFPGL 873

  Fly   534 SMVAAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQ 598
            ..:.::.....|         ||.:|    ...|..|.|.                 :||...||
  Fly   874 GDLHSSHEQQLQ---------QQQYV----RSQPKYQWLD-----------------SPADYAQQ 908

  Fly   599 QQQQPQQQQVPQQQ-----PPPT------------------------PRSSGGGRRGRHSHHQPG 634
            |||..|.||..|||     |.||                        |.|:|.|..|........
  Fly   909 QQQVQQVQQQQQQQQTLVLPGPTSSASSSNAALGVLIPKQENYPDMQPSSNGTGYSGGSGGSSAA 973

  Fly   635 TAAHIAS---------------------------------LMSVRTVRYNRRNNPELEKRRIHHC 666
            .||..|:                                 |:.|:..:|..|.:......|.:.|
  Fly   974 AAAAAAAAAAAVQLAEYSPSTSKGHEILSQVYQQSTVPLKLVPVKPRKYPNRPSKTPVHERPYAC 1038

  Fly   667 DFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCER 731
            ....|.:.:::|..|..|.|||||:||:.|:  .|...|:|||.||.|.|.|||.|||.|.:|.|
  Fly  1039 PVENCDRRFSRSDELTRHIRIHTGQKPFQCR--ICMRSFSRSDHLTTHIRTHTGEKPFSCDICGR 1101

  Fly   732 SFARSD----HLALHMKRHLPKNK 751
            .|||||    |..:|:|:.:.|.|
  Fly  1102 KFARSDEKKRHAKVHLKQRIKKEK 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	31/115 (27%)
		C2H2 Zn finger	671..688	CDD:275368	5/16 (31%)
		zf-H2C2_2	680..707	CDD:290200	12/26 (46%)
		C2H2 Zn finger	696..718	CDD:275368	10/21 (48%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	11/23 (48%)
sr	NP_001262693.1	zf-C2H2	1036..1060	CDD:278523	6/23 (26%)
		C2H2 Zn finger	1038..1060	CDD:275368	6/21 (29%)
		zf-H2C2_2	1052..1077	CDD:290200	12/26 (46%)
		C2H2 Zn finger	1068..1088	CDD:275368	10/21 (48%)
		zf-H2C2_2	1080..1105	CDD:290200	14/24 (58%)
		C2H2 Zn finger	1096..1116	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010