DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and sp1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_012812106.1	Gene:	sp1 / 394744	XenbaseID:	XB-GENE-853336	Length:	760	Species:	Xenopus tropicalis

Alignment Length:	719	Identity:	184/719 - (25%)
Similarity:	262/719 - (36%)	Gaps:	186/719 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 NGAYGCAPLYDGAPYEVALGYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVLWD 233
            |||.|...|    |.|:.|      :|:....||.|...:.........|.....|....|:..
Frog    17 NGAAGSCSL----PLELPL------LAADQEHTSDDMPTIKSENRTGGGYIQKGQDSQPSPLAL- 70

  Fly   234 DITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTG-ESATSQLPQV--------------KMEA 283
             :..:...|:|          ..|.||:|.....|. :.:|:||.|.              |.:|
Frog    71 -LAATCSRIEP----------PENGNGNSQQQGATELDLSTAQLAQTANGWQIISTAGSASKDQA 124

  Fly   284 IDESLLETFSTPLL-SPLEIKTEKQQRQQ------------QHQHQQQQQQQQQQQQQHQQQHQQ 335
            ..::  .:.:.|:. ....:.|...|.||            |:|...|.|....||.|......|
Frog   125 GGDA--SSKNRPIAPGQFVVSTPSVQNQQVLASLQGVMPNIQYQVIPQFQTVDGQQLQFTTAPAQ 187

  Fly   336 QYQQQHYQQHYQ------QQHLYQHHPS----LALPG-LPPAVDVVELQLQQQ--HQQQQHLQH- 386
            ...||.....:|      ||.:..:...    ||:|. |..||.:..:.|...  ..|.|:|.:
Frog   188 VSVQQDASGQFQIIPATNQQIITTNRTGTGNILAMPNLLQQAVPIQGMGLTNNVLSGQTQYLTNV 252

  Fly   387 ----NNSSSSSPKLA---TPGDNSGNTSSYQQQYASQLVSG---SGGGYLNGSSSNSYGYSWHSS 441
                |.:.:..|..|   ||...|...|..|:..:..:.||   |.....:.::|.:|   :.::
Frog   253 PVALNGNITLLPVNAASLTPTSQSVTLSGTQENNSQPVTSGVAISSSQLASQANSGAY---FTNA 314

  Fly   442 QSFHTKYQIHPPSAAASATASATATP------------TAQL-----------------GAQQQQ 477
            .||.|  ...|.:.:....:||.:||            |.||                 |.|.||
Frog   315 NSFST--TTTPSNVSLMNCSSAGSTPGSNVQVQTSQRSTGQLSLLTDSVQQGNGNMQKDGDQNQQ 377

  Fly   478 QQ--------QQQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSS 534
            ||        |..|.:|.| ..|..|..:.|:.:||..:..:....      |.|::.|
Frog   378 QQILIQPQIVQSGQTIQAL-QAAQLSGQAFSTQAISQDALQNLQIQ------TVPNTGP------ 429

  Fly   535 MVAAAAAAAAQRRTTPPPPYQQGHVMGL--INPPP---TLQLLGGAATGSNNSCTTTLTTLTPAS 594
            ::....|.....:.|    :|...:..|  .||..   ||..:.|.:.|.:.| |.|||:: ||.
Frog   430 IIIRTPAVGPNGQVT----WQTIQLQNLQVQNPQAQTITLAPMQGVSLGQSGS-TNTLTSM-PAG 488

  Fly   595 AI----QQQQQQPQQQ------------QVPQQQPPP------TPRSSG------GGRRGRHSHH 631
            .:    .|....|..|            ||.|.|..|      |..:||      .|..|.|..:
Frog   489 TVTVNAAQLSSMPGLQTINLGALGASGIQVHQLQGVPLTITNATGDASGHLSIHATGADGLHDEN 553

  Fly   632 --------------QPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLK 682
                          |||......:...........|.:.:..|::.|.|...||.|||.|:|||:
Frog   554 SAMEEGETSPDPQPQPGRRMRREACTCPYCKEGEGRGSGDPGKKKQHICHIPGCGKVYGKTSHLR 618

  Fly   683 AHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            ||.|.||||:|:.|.|..|..||.|||||.||.|.|||.|.|.|..|.:.|.|||||:.|:|.|
Frog   619 AHLRWHTGERPFVCTWVFCGKRFTRSDELQRHKRTHTGEKKFICPECPKRFMRSDHLSKHIKTH- 682

  Fly   748 PKNK 751
             :||
Frog   683 -QNK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	38/82 (46%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
sp1	XP_012812106.1	DamX	68..>233	CDD:225805	37/178 (21%)
		C2H2 Zn finger	602..624	CDD:275368	13/21 (62%)
		zf-H2C2_2	616..643	CDD:290200	15/26 (58%)
		C2H2 Zn finger	632..654	CDD:275368	13/21 (62%)
		zf-H2C2_2	646..669	CDD:290200	12/22 (55%)
		zf-C2H2	660..682	CDD:278523	11/21 (52%)
		C2H2 Zn finger	662..682	CDD:275368	10/19 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030