DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and SP5

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_011509461.1	Gene:	SP5 / 389058	HGNCID:	14529	Length:	454	Species:	Homo sapiens

Alignment Length:	456	Identity:	130/456 - (28%)
Similarity:	165/456 - (36%)	Gaps:	139/456 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 SSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGGYLNGSSSNSYGYS-WHSSQSFHTKYQIHPP 453
            |.:||....|   :.:.:.::....|.|...:.|.::..:.:...... |..:.|.......|.|
Human    27 SDASPSHFAP---ASSKAGWRLSAPSSLARSARGPHVQVAQAPKVSLGRWDRTPSASPDLGKHSP 88

  Fly   454 SAAASATASATATPTA-------------QLGAQQQQQQQQQQQLQQ----LCPPAAPS---TPS 498
            .|..:||.|....|.|             .||:..:........:..    ..||..||   ||.
Human    89 LALLAATCSRIGQPGAAAPPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQ 153

  Fly   499 TSSSSISSSSASSASRHMFVPPLTPPSSDPGSP---------GSSMVAAAAAA-------AAQRR 547
            .:....|..:|...       ||||| :||..|         .|||.|..|:.       |||..
Human   154 KTHLQPSFGAAHEL-------PLTPP-ADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAA 210

  Fly   548 ----------TTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQ 602
                      ..||||           ||||.:.|      |.|.....|    |..:|.|....
Human   211 LPPGYSNLLPPPPPPP-----------PPPTCRQL------SPNPAPDDL----PWWSIPQAGAG 254

  Fly   603 PQQQQVPQQQPPPTPRSSGGGRRGR-----HSHHQPGTAA------------------------- 637
            |....||           |.|..|.     |:...|.:||
Human   255 PGASGVP-----------GSGLSGACAGAPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQS 308

  Fly   638 HIASLMSVR-----TVRYNRR----------NNPELE--KRRIHHCDFVGCSKVYTKSSHLKAHQ 685
            .||:|:..:     |.|..||          ..||.|  |::.|.|...||.|||.|:||||||.
Human   309 QIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHL 373

  Fly   686 RIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKN 750
            |.||||:|:.|.|..|...|.|||||.||.|.|||.|.|.|..|.:.|.||||||.|:|.|  :|
Human   374 RWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTH--QN 436

  Fly   751 K 751
            |
Human   437 K 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	45/99 (45%)
		C2H2 Zn finger	671..688	CDD:275368	12/16 (75%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	12/21 (57%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	11/19 (58%)
SP5	XP_011509461.1	C2H2 Zn finger	357..376	CDD:275368	13/18 (72%)
		COG5048	<367..440	CDD:227381	43/73 (59%)
		zf-H2C2_2	368..395	CDD:290200	15/26 (58%)
		C2H2 Zn finger	384..406	CDD:275368	12/21 (57%)
		zf-H2C2_2	398..421	CDD:290200	12/22 (55%)
		zf-C2H2	412..434	CDD:278523	12/21 (57%)
		C2H2 Zn finger	414..434	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940