DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and Sp1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001259388.1	Gene:	Sp1 / 31913	FlyBaseID:	FBgn0020378	Length:	726	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	129/486 - (26%)
Similarity:	174/486 - (35%)	Gaps:	132/486 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 HYQQQHLYQHHPSLALPGLPPAVDVVELQLQQQHQQQQHLQHNNSSSSSPKLAT--------PGD 401
            |.|:..:...||||.  |.|.|:...:.             :..|:.|.|.||.        |..
  Fly    30 HLQKPQVNPDHPSLR--GTPLAMLAAQC-------------NKLSNKSPPPLADAAVGKGFHPWK 79

  Fly   402 NSGNTSSYQQQYASQLVSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASATAT 466
            .|.|:.:     |....|..|||...|||:..                 |.|.|.::|::|::
  Fly    80 KSPNSPA-----AGSSGSSGGGGGGGGSSAGQ-----------------HSPCAISAASSSSS-- 120

  Fly   467 PTAQLGAQQQQQQQQ----------QQQLQQLCPPAAPSTPSTSSSSISSSSASSASR------- 514
             :...|.|..:....          .:.|...|......:..:|||:..|.|:|:||.
  Fly   121 -SGSSGGQSSRSLSSSASTMVNITASRPLASSCAAVGGGSTGSSSSASGSQSSSTASAVAAAYGG 184

  Fly   515 HMFVPPLTPPSSD-----PGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQL--- 571
            .::.|..:..:.|     .|..|.....|||......|.....|:      ..:.......:
  Fly   185 DLYFPNTSTSNMDNHHMHQGLLGKVEAGAAAFGGVYSRHPYDWPF------NAVTHKEAASVNSG 243

  Fly   572 -------------LGGAATGSN--NSCTTTLTTLTPASAI---QQQQQQPQQQQVPQQQPPPTPR 618
                         :|||...|.  |..:...::....|.:   |...|...:..:|.|.......
  Fly   244 WWDMHSAAGSWLDMGGAGMHSTMANYASENYSSALSHSLLGSGQHLLQDTYKSMLPGQGVGVGVG 308

  Fly   619 SSGGGRRGRHSHHQPGTAAHIASLM-------------SVRTVRYNRR----------NNPE--- 657
            ...||....||  .|..||..|:..             |..:.|..||          |..|
  Fly   309 VGMGGFSLPHS--SPSAAAAAAATAAAAAGGSPQGGSPSTPSPRSQRRYAGRATCDCPNCQEAER 371

  Fly   658 -------LEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHY 715
                   |.|:.||.|...||.|||.|:||||||.|.||||:|:.|.|..|..||.|||||.||.
  Fly   372 LGPAGVHLRKKNIHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHL 436

  Fly   716 RKHTGAKPFKCIVCERSFARSDHLALHMKRH 746
            |.|||.|.|.|.||.:.|.||||||.|:|.|
  Fly   437 RTHTGEKRFACPVCNKRFMRSDHLAKHVKTH 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	46/115 (40%)
		C2H2 Zn finger	671..688	CDD:275368	12/16 (75%)
		zf-H2C2_2	680..707	CDD:290200	16/26 (62%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	12/19 (63%)
Sp1	NP_001259388.1	C2H2 Zn finger	390..409	CDD:275368	13/18 (72%)
		zf-H2C2_2	401..428	CDD:290200	16/26 (62%)
		C2H2 Zn finger	417..439	CDD:275368	13/21 (62%)
		zf-H2C2_2	431..454	CDD:290200	13/22 (59%)
		zf-C2H2	445..467	CDD:278523	13/21 (62%)
		C2H2 Zn finger	447..467	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	67	1.000	Inparanoid score	I1951
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.990