DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and Klf12

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_038949311.1	Gene:	Klf12 / 306110	RGDID:	1309204	Length:	491	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	140/451 - (31%)
Similarity:	195/451 - (43%)	Gaps:	132/451 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 LALPGLPPAVDVVELQLQQQHQQQQH---------LQHNNSSSSSPKLATPGDNSGNTSSYQQQY 413
            |...|:|......||...:|.....|         |..||.....|:.:.|.|:      :|.|.
  Rat   110 LMFDGMPAVRVKTELLESEQGSPNVHNYPDMEAIPLLLNNVKGEPPEDSLPVDH------FQTQT 168

  Fly   414 ASQLVSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQ 478
            ....:|      :|.:.::                    |:||:|:..|.||:.::
  Rat   169 EPVDLS------INKARTS--------------------PTAASSSPVSMTASASS--------- 198

  Fly   479 QQQQQQLQQLCPPAAPSTPSTSSSSISSS-----SASSASRHMFVPPLTPPSSDPGSPGSSMVAA 538
                        |::.||.|:|||..:||     |.||||          .||...||| .:||:
  Rat   199 ------------PSSTSTSSSSSSRPASSPTVITSVSSAS----------SSSTVLSPG-PLVAS 240

  Fly   539 AAAAAAQR-----RTTPP--PPYQQGHVMGLINP-PPTLQLLGGAATGSNNSCTTTLTTLTP--- 592
            |:....|:     ...||  |...|.:.:..::. |..:|.:....|...:......|.:.|
  Rat   241 ASGMGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLE 305

  Fly   593 ------ASAIQQQQQQPQQQQ-----------------------------VPQQQPPPTPRSSGG 622
                  .:.::.:...|:|.:                             |.:..|.|..|.
  Rat   306 DGRSHGKAQMEPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRV--- 367

  Fly   623 GRRGRHSHHQPGTAAHIASLMSVRTVRYNRRN-NPELEKRRIHHCDFVGCSKVYTKSSHLKAHQR 686
              ||...::|....:  .|..|:.:.|..||: :|:..|||||.|||.||:||||||||||||:|
  Rat   368 --RGNRMNNQKFACS--ISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRR 428

  Fly   687 IHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            .|||||||.|.|..|.|:||||||||||||||||.|||||..|:|||:||||||||.:||:
  Rat   429 THTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHM 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	57/83 (69%)
		C2H2 Zn finger	671..688	CDD:275368	14/16 (88%)
		zf-H2C2_2	680..707	CDD:290200	18/26 (69%)
		C2H2 Zn finger	696..718	CDD:275368	16/21 (76%)
		zf-H2C2_2	710..735	CDD:290200	20/24 (83%)
		C2H2 Zn finger	726..746	CDD:275368	13/19 (68%)
Klf12	XP_038949311.1	KLF12_N	116..313	CDD:410608	54/260 (21%)
		COG5048	<314..490	CDD:227381	84/183 (46%)
		C2H2 Zn finger	408..430	CDD:275368	18/21 (86%)
		C2H2 Zn finger	438..460	CDD:275368	16/21 (76%)
		zf-H2C2_2	452..477	CDD:404364	20/24 (83%)
		C2H2 Zn finger	468..488	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010