DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and Klf1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_006255316.1	Gene:	Klf1 / 304666	RGDID:	1309398	Length:	381	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	113/337 - (33%)
Similarity:	129/337 - (38%)	Gaps:	116/337 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 QIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSASSAS 513
            |..||. :.||.|......|..||:::......        |...|.||..
  Rat   123 QFAPPE-SLSAYAGGPGLVTGPLGSEEHAGWAH--------PTPRPPTPEP-------------- 164

  Fly   514 RHMFVPP-LTP---PSSDPGSPGSSMVAA------AAAAAAQRRTTP-----------PPPYQQG 557
               ||.| |.|   |.:.|....|..|:|      |..|.....:.|           |.|..||
  Rat   165 ---FVAPVLAPGLAPKAQPAFSESRAVSAGGFFPRAGLAVPAAPSAPYGLLSGYPALYPAPQYQG 226

  Fly   558 HVM----------GLINPPPTLQLLGGAATGSNNSCTTTL--TTLTPASAIQQQQQQPQQQQVPQ 610
            |..          |...||..|..||..|.|:....|...  ..|:|.:|
  Rat   227 HFQLFRGLAAPSAGPTAPPSFLNCLGPGAVGTELGATAIAGDAGLSPGAA--------------- 276

  Fly   611 QQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVY 675
               ||        :|.|.:..|...|||.                          |...||.|.|
  Rat   277 ---PP--------KRSRRTLAQKRQAAHT--------------------------CGHEGCGKSY 304

  Fly   676 TKSSHLKAHQRIHT-----GEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFAR 735
            |||||||||.|.||     |||||.|.|..|.||||||||||||||||||.:||.|.:|.|:|:|
  Rat   305 TKSSHLKAHLRTHTAPCPSGEKPYACSWDGCNWRFARSDELTRHYRKHTGHRPFCCGLCPRAFSR 369

  Fly   736 SDHLALHMKRHL 747
            ||||||||||||
  Rat   370 SDHLALHMKRHL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	43/87 (49%)
		C2H2 Zn finger	671..688	CDD:275368	13/16 (81%)
		zf-H2C2_2	680..707	CDD:290200	19/31 (61%)
		C2H2 Zn finger	696..718	CDD:275368	17/21 (81%)
		zf-H2C2_2	710..735	CDD:290200	17/24 (71%)
		C2H2 Zn finger	726..746	CDD:275368	14/19 (74%)
Klf1	XP_006255316.1	EKLF_TAD1	40..65	CDD:293437
		EKLF_TAD2	81..103	CDD:293438
		zf-C2H2	293..317	CDD:278523	16/49 (33%)
		COG5048	<297..>380	CDD:227381	58/82 (71%)
		C2H2 Zn finger	298..317	CDD:275368	14/18 (78%)
		zf-C2H2	328..352	CDD:278523	18/23 (78%)
		C2H2 Zn finger	330..352	CDD:275368	17/21 (81%)
		zf-H2C2_2	344..369	CDD:290200	17/24 (71%)
		C2H2 Zn finger	360..380	CDD:275368	14/19 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010