DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and wt1a

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_571121.1	Gene:	wt1a / 30245	ZFINID:	ZDB-GENE-980526-558	Length:	419	Species:	Danio rerio

Alignment Length:	432	Identity:	112/432 - (25%)
Similarity:	157/432 - (36%)	Gaps:	107/432 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 LPGLPPAVDVVELQLQQQHQQQQHLQHNNSSSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGG 424
            ||.:||                  |...|.:.:.|..:||            |:...|...:|..
Zfish    12 LPPVPP------------------LPGGNGNCTLPVSSTP------------QWPPMLDFHTGAP 46

  Fly   425 YLNGSSSNSYGYSWHS----SQSFHTKYQIHPPSAAASA-----TASATATPTAQLGAQQQQQQQ 480
            |  ||.:.      ||    ..|:.|......|....||     :...|.|...:.||.......
Zfish    47 Y--GSLAQ------HSFIKQEPSWGTADPHEDPHCGLSAFTVHFSGQFTGTGACRYGAFGAPAAS 103

  Fly   481 QQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFVPPL----------TPPSSDPGSPGSSM 535
            |.       ||:.|...|.|....:...:.|:||:.....:          ||....|..|..|.
Zfish   104 QP-------PPSQPRMFSNSPYLSNCMDSQSSSRNQGYGTVAFDGASNYGHTPSHHTPQFPNHSF 161

  Fly   536 -----VAAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTL--TPA 593
                 :...:....|:...|||.|                   |..|.| :|||.:...|  .|.
Zfish   162 KHEDSITQQSNMGDQQYPVPPPVY-------------------GCHTPS-DSCTGSQALLLRNPY 206

  Fly   594 SAIQQQQQQPQQQQV----PQQQPPPTPRSSGGGRRG------------RHSHHQPGTAAHIASL 642
            ::.....|...|.:.    |......|.:|..||...            ::..|..|....:..:
Zfish   207 NSSDNLYQMASQLECMGWNPVNSLASTIKSHPGGYESDPSTPMVYSCSTQYRIHTHGVFRGLQDV 271

  Fly   643 MSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFAR 707
            ..|..:......:.|..::|...|.:.||:|.|.|.|||:.|.|.|||||||.|.:.:|..||:|
Zfish   272 RRVPGITPAIVRSTETNEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFTDCGRRFSR 336

  Fly   708 SDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPK 749
            ||:|.||.|:|||.|||:|..|:|.|:|||||..|.:.|..|
Zfish   337 SDQLKRHQRRHTGVKPFQCETCQRKFSRSDHLKTHTRTHTGK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	36/82 (44%)
		C2H2 Zn finger	671..688	CDD:275368	9/16 (56%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	11/21 (52%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
wt1a	NP_571121.1	WT1	1..291	CDD:280348	64/343 (19%)
		COG5048	286..>411	CDD:227381	49/93 (53%)
		C2H2 Zn finger	298..317	CDD:275368	10/18 (56%)
		zf-H2C2_2	309..336	CDD:290200	15/26 (58%)
		C2H2 Zn finger	325..347	CDD:275368	11/21 (52%)
		zf-H2C2_2	340..364	CDD:290200	14/23 (61%)
		C2H2 Zn finger	355..375	CDD:275368	10/19 (53%)
		C2H2 Zn finger	386..408	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010