DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and Klf8

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	XP_006528923.2	Gene:	Klf8 / 245671	MGIID:	2442430	Length:	457	Species:	Mus musculus

Alignment Length:	324	Identity:	115/324 - (35%)
Similarity:	151/324 - (46%)	Gaps:	61/324 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 QIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQ--LCPPAAPSTPSTSSSSISSSSASS 511
            :|.||.....:..:........|...:.:...|...:.|  :.||..|:.|.......|:.:.:|
Mouse   166 KIEPPEELLESDFNMPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPPTAPQAIMVPTSADTVTS 230

  Fly   512 ASRHMFVPP-LTPPS---SDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHVMGLINPPPTLQLL 572
            |:    :|. |||.|   |..|:.|..::...        .|.|.......:.||...|..:|.|
Mouse   231 AA----IPTVLTPGSILASSQGTGGQPILHVI--------HTIPSVSLPNKMSGLKTIPLVVQSL 283

  Fly   573 GGAAT-----GSNNSCTTTL----------TTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSS-G 621
            ....|     ||..:.|..|          ..:.|||            ..|.:.|..:..|: .
Mouse   284 PMVYTSLPTDGSPAAITVPLIGGDGKSAGSVKVDPAS------------MCPLEFPSDSDESAIE 336

  Fly   622 GGRRGRHS----HHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLK 682
            .|.....|    ||:|.|..|:....|:           :|::||||.|||.|||||||||||||
Mouse   337 SGSSALQSLQGFHHEPATMVHMQGEESL-----------DLKRRRIHQCDFAGCSKVYTKSSHLK 390

  Fly   683 AHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRH 746
            ||:|||||||||.|.|..|.|:||||||||||:|||||.|||:|..|.|||:|||||:||.:||
Mouse   391 AHRRIHTGEKPYKCTWDGCSWKFARSDELTRHFRKHTGIKPFRCTDCNRSFSRSDHLSLHRRRH 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	53/82 (65%)
		C2H2 Zn finger	671..688	CDD:275368	15/16 (94%)
		zf-H2C2_2	680..707	CDD:290200	19/26 (73%)
		C2H2 Zn finger	696..718	CDD:275368	15/21 (71%)
		zf-H2C2_2	710..735	CDD:290200	18/24 (75%)
		C2H2 Zn finger	726..746	CDD:275368	12/19 (63%)
Klf8	XP_006528923.2	KLF8_N	147..314	CDD:410607	33/159 (21%)
		COG5048	370..>440	CDD:227381	54/69 (78%)
		C2H2 Zn finger	374..396	CDD:275368	19/21 (90%)
		C2H2 Zn finger	404..426	CDD:275368	15/21 (71%)
		zf-C2H2	432..454	CDD:395048	13/21 (62%)
		C2H2 Zn finger	434..454	CDD:275368	12/19 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4035
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.060