DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and Zfp352

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_694742.2	Gene:	Zfp352 / 236537	MGIID:	2387418	Length:	551	Species:	Mus musculus

Alignment Length:	668	Identity:	129/668 - (19%)
Similarity:	216/668 - (32%)	Gaps:	184/668 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 SGASEAWPHLPAPSYASDVPHAQQQQLQPAGSPNSNSNGAYGCAPLYDGAPYEVALGYGGAVV-- 194
            :|||:     |.|.           ..||  ||..:|.       |:.|...|: |.:...|:
Mouse     7 TGASQ-----PGPC-----------NTQP--SPVESSQ-------LFSGQSSEM-LTWKQTVMES 45

  Fly   195 --ASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVLWD-DITTSIQNIDPENALMLSSSGSS 256
              .||...|.:.....|..|.....:..|.::     ..|: .:.::.|.|.|.
Mouse    46 ASCSTQETTCTQNSTAYPGKAIGFHFGQPFEN-----TSWNQQVVSAEQKISPA----------- 94

  Fly   257 NNNGSSNSSSNTGESATSQLPQVKMEAIDESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQ 321
               |..::..|:.....  ||..|...:|..  |||..   ....::|....:....|:....:.
Mouse    95 ---GLYHTQLNSAPQIC--LPPQKTTRVDTR--ETFYN---EDYWMRTLNSDKTLLTQNTAMCEN 149

  Fly   322 QQQQQQQHQ----QQHQQQ-------YQQQH----YQQHYQQQ---HLYQHHPSLALPG----LP 364
            |:.....||    ..|..|       :..:|    |..|...:   ||..:...:..|.    |.
Mouse   150 QRVTFDNHQIALYGSHAGQDPNVGHAFASEHDWTSYNSHMTTRNGGHLTLYESQMTAPSCSQTLH 214

  Fly   365 PAVDVVELQLQQQHQ-QQQHLQHNNSSSSSPKLATPG----------DNSGNTSSYQQQYASQLV 418
            |...:.....|...: ||.:|..||....:..:...|          .|...|:...:.::.|.|
Mouse   215 PNQIITSFSEQNYFEDQQSNLAVNNGFYGNQVILPNGYQAFYEPQMRANFDQTNDQMKSFSGQNV 279

  Fly   419 SGSGGGYLNGSSSNSYGY---SWHSSQSFHTKYQIHPPSAAASATASATATPTAQLGAQQQQQQQ 480
            .......|:|..|.| ||   .:...|......|:..|......:...|.|.:........::.:
Mouse   280 CKGQENLLSGECSLS-GYQTSGYRCDQDLIVNPQVTSPIGGQPLSDFQTQTSSFDTALPGSKRTR 343

  Fly   481 QQQQLQQLCPPAAPSTPSTSSSSISSSSASSASRHMFV----PPLTPPSSDPGSPGSSMVAAAAA 541
            ...:....||  ..::|::..:.......:|..::.:.    .|....|.||.....|:.|....
Mouse   344 PSAEDNLACP--LETSPTSEETLYLGQMRTSVDQNFYSSQNGTPNIKESLDPQVTSFSLQAPYVG 406

  Fly   542 AAAQRRTTPPPPYQQGHVMGLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQ 606
            .::....:|           ||...|           ..||..::|.          |:|.|:.:
Mouse   407 ESSYPSCSP-----------LIQKQP-----------QKNSSASSLV----------QRQHPEMK 439

  Fly   607 -----QVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHC 666
                 |.|..|..|:|                                           .:::.|
Mouse   440 LDFKTQSPVSQKDPSP-------------------------------------------LKLYFC 461

  Fly   667 DFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCER 731
            .:.||:|.|.::.|||.||:.||.::.|.|..|.|.|.|.|..:|.||..||.|.:.:.|.:|..
Mouse   462 TYKGCTKFYKRAYHLKEHQKKHTDKRKYGCDEPGCTWSFFRLCDLNRHKEKHNGERFYACPLCST 526

  Fly   732 SFARSDHLALHMKRHLPK 749
            :::|    .|::|:||.|
Mouse   527 NYSR----LLYLKKHLEK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	25/82 (30%)
		C2H2 Zn finger	671..688	CDD:275368	8/16 (50%)
		zf-H2C2_2	680..707	CDD:290200	13/26 (50%)
		C2H2 Zn finger	696..718	CDD:275368	9/21 (43%)
		zf-H2C2_2	710..735	CDD:290200	8/24 (33%)
		C2H2 Zn finger	726..746	CDD:275368	5/19 (26%)
Zfp352	NP_694742.2	C2H2 Zn finger	464..483	CDD:275368	9/18 (50%)
		C2H2 Zn finger	491..513	CDD:275368	9/21 (43%)
		C2H2 Zn finger	521..538	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030