DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and Sp3

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001018052.1	Gene:	Sp3 / 20687	MGIID:	1277166	Length:	783	Species:	Mus musculus

Alignment Length:	759	Identity:	183/759 - (24%)
Similarity:	270/759 - (35%)	Gaps:	205/759 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 HLHQHHSHSLQSGESGA-------------------SEAWPHLP-------APSYASDVPHAQQQ 156
            :|.|......|.|...|                   |:..|..|       |.:.|:.||.|
Mouse    30 YLQQQQQQQQQHGNGAAAAAAQDTQPSPLALLAATCSKIGPPSPGDDDEEAAVAAAAGVPAA--- 91

  Fly   157 QLQPAGSPNSNSNGAYGCAP----LYDGAPYEVALGYGGAVVASTGGATSSDKEY---LYETKNK 214
               .||:....::...|.||    :....|..:. ...|.:|...|.||||. :|   |...:|:
Mouse    92 ---AAGATGDLASAQLGGAPNRWEVLSATPTTIK-DEAGNLVQIPGAATSSG-QYVLPLQNLQNQ 151

  Fly   215 EALYADPLDD---------PYQRPVLWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNTGE 270
            :.....|..|         .||       :...||:.|.:. :.:..:|||:|.|.:..:|
Mouse   152 QIFSVAPGSDSSNGTVSNVQYQ-------VIPQIQSTDAQQ-VQIGFTGSSDNGGINQENS---- 204

  Fly   271 SATSQLPQVKMEAIDESLLETFSTPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQQQQQHQQQHQQ 335
                   |:::.......|....||   |..|         |:...|..|.|.|...........
Mouse   205 -------QIQIIPGSNQTLLASGTP---PANI---------QNLIPQTGQVQVQGVAIGGSSFPG 250

  Fly   336 QYQQQHYQQHYQQQHLYQHHPSLALPG----LP-PAVDVVELQLQQQHQQQ-------------- 381
            |.|            :..:.| |.|||    :| .:||:..|.|....|..
Mouse   251 QTQ------------VVANVP-LGLPGNITFVPINSVDLDSLGLSGSSQTMTAGINADGHLINTG 302

  Fly   382 QHLQHNNSSSSSPKLATPGDNSGN--------TSSYQQQYASQL---VSGSGGGYLNGSSSNSYG 435
            |.:..:::|..:.:..:|..|..|        |||     :|||   :..:|....|.:|..:..
Mouse   303 QAMDSSDNSERTGERVSPDVNETNADTDLFVPTSS-----SSQLPVTIDSTGILQQNTNSLTTTS 362

  Fly   436 YSWHSS--QSFHTKYQIHPPSAAASATASATATPTAQ-LGAQQQQQQQQQQQLQQLCPPAAPSTP 497
            ...|||  |..:.:..:...:.|.:...| ||.|..| |..|..||...|.|:.|...|......
Mouse   363 GQVHSSDLQGNYIQSPVSEETQAQNIQVS-TAQPVVQHLQLQDSQQPTSQAQIVQGITPQTIHGV 426

  Fly   498 STSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAAAAQRRTTPPPPYQQGHVMGL 562
            ..|..:||..:..:....:             :||:.::.|.....:.:.|     :|...|.|:
Mouse   427 QASGQNISQQALQNLQLQL-------------NPGTFLIQAQTVTPSGQIT-----WQTFQVQGV 473

  Fly   563 IN-----------------PPPTLQL----LGGAATGSNNSCTT----TLTTLT----PASAIQ- 597
            .|                 |..||.|    .|||.|.:..|.:|    .|.|:|    .::.||
Mouse   474 QNLQNLQIQNTAAQQITLTPVQTLTLGQVAAGGALTSTPVSLSTGQLPNLQTVTVNSIDSTGIQL 538

  Fly   598 ---QQQQQPQQQQVPQQQPPPTPRSSGG-----------------GRRGRHSHHQPGTAAHIASL 642
               :....|...::.:::|.|......|                 ...|...|.:......:|
Mouse   539 HPGENADSPADIRIKEEEPDPEEWQLSGDSTLNTNDLTHLRVQVVDEEGDQQHQEGKRLRRVA-- 601

  Fly   643 MSVRTVRYNRRNNPELEKRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFAR 707
            .:....:........|.|::.|.|...||.|||.|:|||:||.|.|:||:|:.|.|..|..||.|
Mouse   602 CTCPNCKEGGGRGTNLGKKKQHICHIPGCGKVYGKTSHLRAHLRWHSGERPFICNWMFCGKRFTR 666

  Fly   708 SDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK 751
            ||||.||.|.|||.|.|.|..|.:.|.||||||.|:|.|  :||
Mouse   667 SDELQRHRRTHTGEKKFVCPECSKRFMRSDHLAKHIKTH--QNK 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	37/82 (45%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	14/26 (54%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	11/19 (58%)
Sp3	NP_001018052.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		5/24 (21%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	140..239		26/129 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..340		8/42 (19%)
		Transactivation domain (Gln-rich). /evidence=ECO:0000250	352..501		35/167 (21%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q02447	463..471		2/12 (17%)
		Repressor domain. /evidence=ECO:0000250	536..622		11/87 (13%)
		C2H2 Zn finger	625..647	CDD:275368	13/21 (62%)
		COG5048	<638..720	CDD:227381	42/73 (58%)
		zf-H2C2_2	639..666	CDD:290200	14/26 (54%)
		C2H2 Zn finger	655..677	CDD:275368	13/21 (62%)
		zf-H2C2_2	669..692	CDD:290200	12/22 (55%)
		zf-C2H2	683..705	CDD:278523	12/21 (57%)
		C2H2 Zn finger	685..705	CDD:275368	11/19 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940