DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and Sp1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_038700.2	Gene:	Sp1 / 20683	MGIID:	98372	Length:	781	Species:	Mus musculus

Alignment Length:	838	Identity:	200/838 - (23%)
Similarity:	269/838 - (32%)	Gaps:	279/838 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SNNNHS----------------SNSSSNNSNG---SQTPNGNNNSSLATGGHQHHQFHHHLHHHH 108
            |:.:||                :|..|.|..|   |||.:.:..||.::||
Mouse     2 SDQDHSMDEVTAVVKIEKDVGGNNGGSGNGGGAAFSQTRSSSTGSSSSSGG-------------- 52

  Fly   109 SHQHHHQHHHLHQHHSHSLQSGESGASEAWPHLPAPSYASDVPHAQQQQLQPAGSPNSNSNGAYG 173
                                   .|..|:.|. |....|:.....:        |||.|||.:.|
Mouse    53 -----------------------GGGQESQPS-PLALLAATCSRIE--------SPNENSNNSQG 85

  Fly   174 CAPLYDGAPYEVAL--------GYGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPV 230
              |...|...|:.|        ..|..:::|:.|||.:.||
Mouse    86 --PSQSGGTGELDLTAAQLSQGANGWQIISSSSGATPTSKE------------------------ 124

  Fly   231 LWDDITTSIQNIDPENALMLSSSGSSNNNGSSNSSSNT---GESATSQLPQVKMEAIDESLLETF 292
                                 .||:| .|||.:|.:.|   |:...:..|.::.:.:...|
Mouse   125 ---------------------QSGNS-TNGSESSKNRTVSGGQYVVAATPNLQNQQVLTGL---- 163

  Fly   293 STPLLSPLEIKTEKQQRQQQHQHQQQQQQQQQ---QQQQHQQQHQQQYQ------QQHYQQHYQQ 348
              |.:.|      ..|.|...|.|....||.|   ...|.||....|.|      ||........
Mouse   164 --PGVMP------NIQYQVIPQFQTVDGQQLQFAATGAQVQQDGSGQIQIIPGANQQIIPNRGSG 220

  Fly   349 QHLYQHHPSL---ALPGLPPAVDVVELQLQQQHQQQQHLQHNNS----SSSSPKLATPGDNSGNT 406
            .::....|:|   |:|....|.:|:..|.|........|..|.:    :|.|....||...:|..
Mouse   221 GNIIAAMPNLLQQAVPLQGLANNVLSGQTQYVTNVPVALNGNITLLPVNSVSAATLTPSSQAGTI 285

  Fly   407 SSYQQQYASQLVSGSGGGYLNGSSSNSYGYSWHSSQSFHTKYQIHP-------------PSAAAS 458
            ||...|.:|.....||    ...||.|...|..||.||.|....:.             .|:.:|
Mouse   286 SSSGSQESSSQPVTSG----TAISSASLVSSQASSSSFFTNANSYSTTTTTSNMGIMNFTSSGSS 346

  Fly   459 ATASATATP--------TAQLGAQQQQ---------------QQQQQQQLQQLCPP--------- 491
            .|:|...||        :..|..||.|               |.||.||.|.|..|
Mouse   347 GTSSQGQTPQRVGGLQGSDSLNIQQNQTSGGSLQGSQQKEGEQSQQTQQQQILIQPQLVQGGQAL 411

  Fly   492 ----AAPSTPSTSSSSISSSSASSASRHMFVPPLTP-----PSSDPGSPGSSMVAAAAAAAAQRR 547
                |||.:..|.::...|.......:...|....|     |:..|....|...........|
Mouse   412 QALQAAPLSGQTFTTQAISQETLQNLQLQAVQNSGPIIIRTPTVGPNGQVSWQTLQLQNLQVQ-- 474

  Fly   548 TTPPPPYQQGHVMGLINPPP---TLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVP 609
                            ||..   ||..:.|.:.|..:|..||||.:..|::|..........|:.
Mouse   475 ----------------NPQAQTITLAPMQGVSLGQTSSSNTTLTPIASAASIPAGTVTVNAAQLS 523

  Fly   610 QQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASL-----------------MSVRTVRYNRRNNPE 657
            ......|...|..|..|...|..||....||:.                 :...|......|:.:
Mouse   524 SMPGLQTINLSALGTSGIQVHQLPGLPLAIANTPGDHGTQLGLHGSGGDGIHDETAGGEGENSSD 588

  Fly   658 LE-----------------------------KRRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKP 693
            |:                             |::.|.|...||.|||.|:|||:||.|.||||:|
Mouse   589 LQPQAGRRTRREACTCPYCKDSEGRASGDPGKKKQHICHIQGCGKVYGKTSHLRAHLRWHTGERP 653

  Fly   694 YTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHLPKNK 751
            :.|.|..|..||.|||||.||.|.|||.|.|.|..|.:.|.|||||:.|:|.|  :||
Mouse   654 FMCNWSYCGKRFTRSDELQRHKRTHTGEKKFACPECPKRFMRSDHLSKHIKTH--QNK 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	40/128 (31%)
		C2H2 Zn finger	671..688	CDD:275368	11/16 (69%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	13/24 (54%)
		C2H2 Zn finger	726..746	CDD:275368	10/19 (53%)
Sp1	NP_038700.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..95		28/140 (20%)
		Repressor domain. /evidence=ECO:0000250	2..84		25/127 (20%)
		Transactivation domain A (Gln-rich). /evidence=ECO:0000250	145..250		25/116 (22%)
		Transactivation domain B (Gln-rich). /evidence=ECO:0000250	260..494		56/255 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..300		5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..395		13/64 (20%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P08047	461..469		1/7 (14%)
		Transactivation domain C (highly charged). /evidence=ECO:0000250	495..608		20/112 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..595		3/31 (10%)
		VZV IE62-binding. /evidence=ECO:0000250	617..781		51/95 (54%)
		C2H2 Zn finger	626..648	CDD:275368	13/21 (62%)
		COG5048	<639..710	CDD:227381	42/73 (58%)
		zf-H2C2_2	640..667	CDD:290200	15/26 (58%)
		C2H2 Zn finger	656..678	CDD:275368	13/21 (62%)
		zf-H2C2_2	670..693	CDD:290200	12/22 (55%)
		zf-C2H2	684..706	CDD:278523	11/21 (52%)
		C2H2 Zn finger	686..706	CDD:275368	10/19 (53%)
		Domain D. /evidence=ECO:0000250	706..781		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940