DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dar1 and hbl-1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001041243.1	Gene:	hbl-1 / 180848	WormBaseID:	WBGene00001824	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	729	Identity:	142/729 - (19%)
Similarity:	236/729 - (32%)	Gaps:	213/729 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 ASEAW--PHLP---------APSYASDVPHAQQQQLQPAG---SPNSNSNGAYG--CAPLYDGAP 182
            |..||  ..:|         .|...|:.|        |.|   |.|:||.|.:.  |.|   |:.
Worm    14 AKPAWRLQQMPVQLSNFVSKTPLIGSEWP--------PTGDWRSANNNSLGDWNKCCVP---GSE 67

  Fly   183 YEVALG-YGGAVVASTGGATSSDKEYLYETKNKEALYADPLDDPYQRPVLWDDITTSIQNIDPEN 246
            ....|| :|.:.:.........:|.:      .:..|..|.:|             ..::.:..|
Worm    68 IPQHLGPFGNSSLTMLTAQQPGEKIH------PDGGYVSPKED-------------GRKSSEHTN 113

  Fly   247 ALMLSSSGSSNNNGSSNSSSNTGESATSQLPQVKMEAID-ESLLETFSTPLLSPLEIKTEKQQRQ 310
            :..:|:|.|.:|:|:.:.|::.             |.|| |.:.||         |:.|:::...
Worm   114 SYDVSASQSPSNDGAQSDSTSD-------------EHIDVECMTET---------EMDTDEKDST 156

  Fly   311 QQHQHQQQQQQQQQQQQQHQQQHQQQYQQQHYQQHYQQQHLYQHH----PSLALPGLPPAVDVVE 371
            .:.:.|...:.::....: .:....:....:||...:...:.|..    ||.....||..:.:..
Worm   157 IKPEDQATPKLEEGSDSK-PESTSVEGTSSNYQVTSEPVQMPQMPIPVIPSFLKNSLPAPIPITP 220

  Fly   372 LQLQQQHQQQQHLQHNNSSSSSPKLATPGDNSGNTSSYQQQYASQLVSGSGGGYLNGSSSNSYGY 436
                   .|..:::.:||.|....|..       |.| |||:|......:   .:..|||.|.|:
Worm   221 -------TQSANVERSNSPSIEEALLL-------TLS-QQQFAEVFAEAA---KIRKSSSESIGF 267

  Fly   437 SWHSSQSFHTKYQIHPP-----------SAAASATASATATPTAQ----------LGAQQQQQQQ 480
            ....:.:|   ..|.|.           ..|.::|.||.:|||..          ||.......|
Worm   268 QRSGTSAF---LNIEPKEMSMSSANNNNEEAPASTVSACSTPTTTTSASFCRPPGLGPVALPPTQ 329

  Fly   481 QQQQLQQLCPPAAPSTPS---------------TSSSSISSSSASSASRHM-------------- 516
            ..|....:||......||               .|....:|.:.....:||
Worm   330 NGQTPMLVCPICGFMCPSKFHFNSHMNTHGDHQCSMCDYTSRTEGRLKKHMRESHTVEEQLRAGF 394

  Fly   517 FVPPLTPPSSDP--------GSPGS-------------SMVAAAAAAAAQRRTTPPPPYQQGHVM 560
            ...|....:|.|        ||..|             |::.:...|.:...||..|.......:
Worm   395 ESEPAKESASSPKNLSLSKDGSATSPINEIFNLSTTMASILDSTNNAVSSTSTTEQPSALSALTL 459

  Fly   561 GLINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQ-QPQ------------QQQVPQQQ 612
            .:.:.|..|..|..::.|        ::.|....||.:... .|:            ...:....
Worm   460 DMSSTPSLLSTLAHSSFG--------VSALDQIKAISENPSFMPEGGINLASALGVVSNAIKGDT 516

  Fly   613 PPPTPRSSGGGRRG----------RHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEKRRIHHCD 667
            |.|..:|:|..||.          :...||        ||.......:.|.:.|..::....||:
Worm   517 PSPEKQSNGECRRSSSGKIKIFKCKQCGHQ--------SLSKDDQWAHARTHIPAEKQLNCQHCN 573

  Fly   668 FVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERS 732
            ||...|     .||:.|.|.|.|.||:.|:  :|.:.......|..|.:.||....|:|:.|..:
Worm   574 FVTEYK-----HHLEYHYRNHIGSKPFQCK--KCAYNCVNKSMLNSHMKSHTNHYQFRCMDCTYA 631

  Fly   733 FARSDHLALHMKRH 746
            ......|.||:|::
Worm   632 TKYCHSLKLHLKKY 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	23/82 (28%)
		C2H2 Zn finger	671..688	CDD:275368	5/16 (31%)
		zf-H2C2_2	680..707	CDD:290200	10/26 (38%)
		C2H2 Zn finger	696..718	CDD:275368	4/21 (19%)
		zf-H2C2_2	710..735	CDD:290200	7/24 (29%)
		C2H2 Zn finger	726..746	CDD:275368	6/19 (32%)
hbl-1	NP_001041243.1	C2H2 Zn finger	338..358	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..384	CDD:275368	4/20 (20%)
		C2H2 Zn finger	569..589	CDD:275368	9/24 (38%)
		zf-H2C2_2	581..602	CDD:290200	10/22 (45%)
		C2H2 Zn finger	597..617	CDD:275368	4/21 (19%)
		zf-H2C2_2	609..634	CDD:290200	7/24 (29%)
		C2H2 Zn finger	625..643	CDD:275368	5/17 (29%)
		C2H2 Zn finger	931..951	CDD:275368
		C2H2 Zn finger	959..982	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000