DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and KLF14

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_619638.2	Gene:	KLF14 / 136259	HGNCID:	23025	Length:	323	Species:	Homo sapiens

Alignment Length:	281	Identity:	93/281 - (33%)
Similarity:	119/281 - (42%)	Gaps:	56/281 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 PPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPPSS---DPGSPGSSMVAAAAAAAAQRRTTPP 551
            ||........:.|.:.::               ||.|   .||.||.:.|.......|      |
Human    29 PPDPEGAGGAAGSEVGAA---------------PPESALPGPGPPGPASVPQLPQVPA------P 72

  Fly   552 PPYQQGHVMGLINPPPTLQLLGGAATGS-NNS---------------CT--TTLTTLTPAS---A 595
            .|...|....|:.......|.|.:..|| .||               |:  |..:.|.|||   |
Human    73 SPGAGGAAPHLLAASVWADLRGSSGEGSWENSGEAPRASSGFSDPIPCSVQTPCSELAPASGAAA 137

  Fly   596 IQQQQQQPQQQQVPQQQPPPTPRSSGGGRRGRHSHHQPGTAAHIASLMSVRTVRYNRRNNPELEK 660
            :...:.......||.....|...::.||..|......|..||..|.         .||:.....|
Human   138 VCAPESSSDAPAVPSAPAAPGAPAASGGFSGGALGAGPAPAADQAP---------RRRSVTPAAK 193

  Fly   661 RRIHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFK 725
            |  |.|.|.||:|.|.||||||:|||.||||:|::|.|.:|:.:|.|||||.||||.|||.|.|.
Human   194 R--HQCPFPGCTKAYYKSSHLKSHQRTHTGERPFSCDWLDCDKKFTRSDELARHYRTHTGEKRFS 256

  Fly   726 CIVCERSFARSDHLALHMKRH 746
            |.:|.:.|:|||||..|.:||
Human   257 CPLCPKQFSRSDHLTKHARRH 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	42/82 (51%)
		C2H2 Zn finger	671..688	CDD:275368	12/16 (75%)
		zf-H2C2_2	680..707	CDD:290200	15/26 (58%)
		C2H2 Zn finger	696..718	CDD:275368	13/21 (62%)
		zf-H2C2_2	710..735	CDD:290200	14/24 (58%)
		C2H2 Zn finger	726..746	CDD:275368	9/19 (47%)
KLF14	NP_619638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..80		15/71 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..161		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..195		9/39 (23%)
		COG5048	198..>283	CDD:227381	48/80 (60%)
		C2H2 Zn finger	200..219	CDD:275368	13/18 (72%)
		C2H2 Zn finger	227..249	CDD:275368	13/21 (62%)
		C2H2 Zn finger	257..277	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	279..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1623
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.790