DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and KLF1

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_006554.1	Gene:	KLF1 / 10661	HGNCID:	6345	Length:	362	Species:	Homo sapiens

Alignment Length:	297	Identity:	108/297 - (36%)
Similarity:	135/297 - (45%)	Gaps:	60/297 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 PPAAPSTPSTSSSSISSSSASSASRHMFVPPLTPPSSDPGSPGSSMVAAAAAA--------AAQR 546
            |..||.|     .:::.|.||.|   .:.||.....:..|.||  :||....:        .|.|
Human    87 PGGAPQT-----CALAPSEASGA---QYPPPPETLGAYAGGPG--LVAGLLGSEDHSGWVRPALR 141

  Fly   547 RTTP---------PPPYQQGHVMGL--INPPPTLQLLGG----------AATGSNNSCTTTLTTL 590
            ...|         |.|..:...:.|  :.|.|.....||          ||:|:.....:....:
Human   142 ARAPDAFVGPALAPAPAPEPKALALQPVYPGPGAGSSGGYFPRTGLSVPAASGAPYGLLSGYPAM 206

  Fly   591 TPASAIQQQQQQPQQQQVPQQQPPPTPR--------SSGGGRRGRHSHHQPGTAAHIASLMSVRT 647
            .||...|...|..:..|.|...|..:|.        :.|.|..|  :...||..|..|.
Human   207 YPAPQYQGHFQLFRGLQGPAPGPATSPSFLSCLGPGTVGTGLGG--TAEDPGVIAETAP------ 263

  Fly   648 VRYNRRNNPELEKRR--IHHCDFVGCSKVYTKSSHLKAHQRIHTGEKPYTCQWPECEWRFARSDE 710
               ::|......::|  .|.|...||.|.||||||||||.|.|||||||.|.|..|.||||||||
Human   264 ---SKRGRRSWARKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACTWEGCGWRFARSDE 325

  Fly   711 LTRHYRKHTGAKPFKCIVCERSFARSDHLALHMKRHL 747
            ||||||||||.:||:|.:|.|:|:|||||||||||||
Human   326 LTRHYRKHTGQRPFRCQLCPRAFSRSDHLALHMKRHL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	46/84 (55%)
		C2H2 Zn finger	671..688	CDD:275368	13/16 (81%)
		zf-H2C2_2	680..707	CDD:290200	19/26 (73%)
		C2H2 Zn finger	696..718	CDD:275368	17/21 (81%)
		zf-H2C2_2	710..735	CDD:290200	17/24 (71%)
		C2H2 Zn finger	726..746	CDD:275368	14/19 (74%)
KLF1	NP_006554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..110		9/30 (30%)
		EKLF_TAD1	22..>42	CDD:293437
		EKLF_TAD2	59..85	CDD:293438
		9aaTAD. /evidence=ECO:0000269\|PubMed:31375868	71..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..271		6/32 (19%)
		zf-C2H2	279..303	CDD:278523	16/23 (70%)
		COG5048	<281..>361	CDD:227381	59/79 (75%)
		C2H2 Zn finger	284..303	CDD:275368	14/18 (78%)
		zf-H2C2_2	295..322	CDD:290200	19/26 (73%)
		C2H2 Zn finger	311..333	CDD:275368	17/21 (81%)
		zf-H2C2_2	325..350	CDD:290200	17/24 (71%)
		C2H2 Zn finger	341..361	CDD:275368	14/19 (74%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010