DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dar1 and klf12b

DIOPT Version :9

Sequence 1:	NP_001097493.1	Gene:	dar1 / 38436	FlyBaseID:	FBgn0263239	Length:	751	Species:	Drosophila melanogaster
Sequence 2:	NP_001103335.1	Gene:	klf12b / 100126139	ZFINID:	ZDB-GENE-071004-22	Length:	341	Species:	Danio rerio

Alignment Length:	329	Identity:	120/329 - (36%)
Similarity:	161/329 - (48%)	Gaps:	50/329 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 TKYQIHPPSAAASATASATATPTAQLGAQQQQQQQQQQQLQQLCPPAAPSTPSTSSSSISSSSAS 510
            :|.:..||....|:....|.|....|...:.:...          |.:.::|.||:.|.||||:|
Zfish    34 SKVKAEPPEDLLSSDQFQTQTEPVDLSINKTRTSS----------PLSNNSPVTSAFSPSSSSSS 88

  Fly   511 SASRHMFVPPLTPPSSDPGSP----GSSMVAAAAAAAAQR-----RTTPPP-----PYQQGHVMG 561
            |:|      |....|...|.|    ..|:|.::.....|:     ...||.     |.|...:..
Zfish    89 SSS------PSVIASVSSGMPSVLTSGSLVGSSHGVRGQQFLHIIHPVPPSSPSKLPSQVHRISV 147

  Fly   562 LINPPPTLQLLGGAATGSNNSCTTTLTTLTPASAIQQQQQQPQQQQVPQQQPPPTPRSSGGG--- 623
            ::...|.:.     .|...:..|.:.|.:.|  .:.:.:.|.:.|..|....|...:|....
Zfish   148 VVQSLPLMY-----TTSVRSPSTLSSTIMLP--LLDEARCQDKAQTDPNGLSPRQIKSDSDDDDL 205

  Fly   624 -RRGRHSHHQPG-TAAHIA----SLMSVRTVRYNRR----NNPELEKRRIHHCDFVGCSKVYTKS 678
             .....|.::.| ||..||    ..||..::...||    .:|:.:|||||.|||.||:||||||
Zfish   206 PNVTLDSVNETGSTALSIARAVQDSMSPFSIESIRRPPPPESPDSKKRRIHRCDFAGCNKVYTKS 270

  Fly   679 SHLKAHQRIHTGEKPYTCQWPECEWRFARSDELTRHYRKHTGAKPFKCIVCERSFARSDHLALHM 743
            ||||||:|.|||||||.|.|..|.|:||||||||||||||||.|||||..|:|||:||||||||.
Zfish   271 SHLKAHRRTHTGEKPYKCTWDGCTWKFARSDELTRHYRKHTGVKPFKCGDCDRSFSRSDHLALHR 335

  Fly   744 KRHL 747
            :||:
Zfish   336 RRHM 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dar1	NP_001097493.1	COG5048	641..>724	CDD:227381	56/86 (65%)
		C2H2 Zn finger	671..688	CDD:275368	14/16 (88%)
		zf-H2C2_2	680..707	CDD:290200	18/26 (69%)
		C2H2 Zn finger	696..718	CDD:275368	16/21 (76%)
		zf-H2C2_2	710..735	CDD:290200	20/24 (83%)
		C2H2 Zn finger	726..746	CDD:275368	13/19 (68%)
klf12b	NP_001103335.1	zf-C2H2	256..280	CDD:278523	19/23 (83%)
		C2H2 Zn finger	258..280	CDD:275368	18/21 (86%)
		zf-H2C2_2	272..>289	CDD:290200	13/16 (81%)
		C2H2 Zn finger	288..310	CDD:275368	16/21 (76%)
		zf-H2C2_2	302..327	CDD:290200	20/24 (83%)
		C2H2 Zn finger	318..338	CDD:275368	13/19 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23235
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010