DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10357 and LPL

DIOPT Version :9

Sequence 1:	NP_647821.2	Gene:	CG10357 / 38435	FlyBaseID:	FBgn0035453	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	277	Identity:	89/277 - (32%)
Similarity:	132/277 - (47%)	Gaps:	35/277 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LIVHGYLGSCTHGSIMP--LRNAYTAQGYENVLVADWGPVANLDYPSSRLAVKNVAQILAKLLEE 119
            :::||:..:..:.|.:|  :...|..:...||:|.||...|...||.|....|.|.|.:|:.:..
Human    77 MVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTKLVGQDVARFINW 141

  Fly   120 FLQRHGISLEGVHVIGHSLGAHIAGRIGRYFNGSLGRVTGLDPALPLFS-SRSDDSLHSNAAQFV 183
            ..:.....|:.||::|:|||||.||..|...|..:.|:||||||.|.|. :.:...|..:.|.||
Human   142 MEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRITGLDPAGPNFEYAEAPSRLSPDDADFV 206

  Fly   184 DVIHT---DYP--LFGDIRPRGTVDFYPNFGLAPQPGC---ENVDVVAASKL--LHEAYSCSHNR 238
            ||:||   ..|  ..|..:|.|.||.|||.|.. ||||   |.:.|:|...|  :.:...|||.|
Human   207 DVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTF-QPGCNIGEAIRVIAERGLGDVDQLVKCSHER 270

  Fly   239 AVMFYAESIGMPEN-FPAVSCSLTAIKSRRVEDCLR-EKSKTNTENANDYQTVFMGEHVN----- 296
            ::..:.:|:...|| ..|..||......:.:  ||. .|::.|.          :|..:|
Human   271 SIHLFIDSLLNEENPSKAYRCSSKEAFEKGL--CLSCRKNRCNN----------LGYEINKVRAK 323

  Fly   297 RSATLYYYLETNGAPPY 313
            ||:.:  ||:|....||
Human   324 RSSKM--YLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10357	NP_647821.2	Pancreat_lipase_like	28..308	CDD:238363	86/270 (32%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	89/277 (32%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		5/22 (23%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010