DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and FIBCD1

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_001138578.1	Gene:	FIBCD1 / 84929	HGNCID:	25922	Length:	461	Species:	Homo sapiens

Alignment Length:	501	Identity:	146/501 - (29%)
Similarity:	217/501 - (43%)	Gaps:	104/501 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LAAIATVMVLAAICGFGTGSVL-----EVPGVTQAPPLPPRNLRNNQTRSRIPNNFRSIATPPIA 64
            |.|:|.::.:|.     ||:||     ..||.                           |.||:
Human    36 LLALAVLLAVAV-----TGAVLFLNHAHAPGT---------------------------APPPV- 67

  Fly    65 PRCDYKELMTNLHDRVGILVTLDE-DQRHRLEVIDKKLDQLVESSSARMESMKAQQLDFLHRLDS 128
                   :.|........|||::. |..|...:||.:...|.: |.||:||.:|..|..|
Human    68 -------VSTGAASANSALVTVERADSSHLSILIDPRCPDLTD-SFARLESAQASVLQAL----- 119

  Fly   129 FEHIQRLSRNTLDELKGETDQVFGPRNVRELKHKLRNRKKMKDISRTVRDVSQEQYPSSGI---- 189
            .||      .....|.|:.:|        ||...|.::     :.|.:...|:.|....|:
Human   120 TEH------QAQPRLVGDQEQ--------ELLDTLADQ-----LPRLLARASELQTECMGLRKGH 165

  Fly   190 GTFNESNLNLSSRLDALATLLASTALSVRSVQVEVANLSRAIRRQSRLIQGKGLRSTPGQQPIFY 254
            ||..:....|.|....|..||:.:...:..:...|:::..|::|.      :||.....:..:..
Human   166 GTLGQGLSALQSEQGRLIQLLSESQGHMAHLVNSVSDILDALQRD------RGLGRPRNKADLQR 224

  Fly   255 GPSGLNGP--TATRQLPSSCSYSFLS---NHGILKVQLTPESESFYVSCD-----EDWTVILSRT 309
            .|:....|  .||...|..|....||   :.|:..|..|.....|.|.||     ..|||...|.
Human   225 APARGTRPRGCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRRE 289

  Fly   310 SDDVNFERGWLDYRDGFGNLAGDFFIGLNKLHALTSSALHELRIVMEDFSGNVAYA-----GYSL 369
            ...|||.|||..||||||.|.|:.::||.::||||:.|.:||.:.:|||....|||     |..|
Human   290 DGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGL 354

  Fly   370 FAIGSEKELYPLVLLGKFQDNLTPSAGDSLSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNN 434
            |::..|::.|||.:.     :.:.:|||||..|:|.:|:|.|:|:|:. |.|||..::||.|:.|
Human   355 FSVDPEEDGYPLTVA-----DYSGTAGDSLLKHSGMRFTTKDRDSDHS-ENNCAAFYRGAWWYRN 413

  Fly   435 CAKSNLFGEYTT-QNQPGETGIWWDTFSG-QNSLKRVRWMIRPISE 478
            |..|||.|:|.. .:.....|:.|.:::| |.|||.....|||:.|
Human   414 CHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVRE 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	86/223 (39%)
FIBCD1	NP_001138578.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..238		3/23 (13%)
		FReD	241..457	CDD:238040	86/221 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	1	1.100	-	-	O	PTHR19143
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.810