DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10359 and Fcna

DIOPT Version :9

Sequence 1:	NP_001137882.1	Gene:	CG10359 / 38434	FlyBaseID:	FBgn0035452	Length:	485	Species:	Drosophila melanogaster
Sequence 2:	NP_112638.2	Gene:	Fcna / 83517	RGDID:	621221	Length:	335	Species:	Rattus norvegicus

Alignment Length:	279	Identity:	98/279 - (35%)
Similarity:	130/279 - (46%)	Gaps:	60/279 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 KGLRSTPGQ--------QPIFYGPSGLNG---------PTATRQL--------PSSCSYSFLSNH 280
            :||:.:||:        :|...||.|:.|         |...::|        |.||  ..|...
  Rat    70 RGLQGSPGKMGPAGSKGEPGTMGPPGVKGEKGERGTASPLGQKELGDALCRRGPRSC--KDLLTR 132

  Fly   281 GILKVQLT-------PESESFYVSCDED-----WTVILSRTSDDVNFERGWLDYRDGFGNLAGDF 333
            ||.   ||       |:.....|.||.|     |||...|....:||.|.|..|:.|||||..:|
  Rat   133 GIF---LTGWYTIYLPDCRPLTVLCDMDVDGGGWTVFQRRVDGSINFYRDWDSYKRGFGNLGTEF 194

  Fly   334 FIGLNKLHALTSSALHELRIVMEDFSGNVAYAGYSLFAIGSEKELYPLVLLGKFQDNLTPSAGDS 398
            ::|.:.||.||::...|||:.:.:|.|..::|.||.|.:..|:|.|.|. ||:|   |..:||||
  Rat   195 WLGNDYLHLLTANGNQELRVDLREFQGQTSFAKYSSFQVSGEQEKYKLT-LGQF---LEGTAGDS 255

  Fly   399 LSYHAGAKFSTVDQDNDNCLECNCALRHKGAGWFNNCAKSNLFGEYTTQNQPGE-----TGIWWD 458
            |:.|....|||.|||||.....|||....||.|:::|.:|||.|.|.    ||.     .||.|
  Rat   256 LTKHNNMAFSTHDQDNDTNGGKNCAALFHGAWWYHDCHQSNLNGRYL----PGSHESYADGINW- 315

  Fly   459 TFSGQN---SLKRVRWMIR 474
             .||:.   |.|.....||
  Rat   316 -LSGRGHRYSYKVAEMKIR 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10359	NP_001137882.1	FReD	267..476	CDD:238040	88/236 (37%)
Fcna	NP_112638.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..114		10/43 (23%)
		Collagen	<67..108	CDD:396114	9/37 (24%)
		FReD	123..333	CDD:238040	85/224 (38%)
		A domain, contributes to trimerization. /evidence=ECO:0000250	123..162		13/43 (30%)
		B domain, contributes to trimerization. /evidence=ECO:0000250	163..251		37/91 (41%)
		Carbohydrate-binding. /evidence=ECO:0000250\|UniProtKB:O00602	291..293		0/1 (0%)
		P domain. /evidence=ECO:0000250\|UniProtKB:O00602	326..335		3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000029
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100073
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X25
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.710